Scientist 1 or 2, Center of Technology, Mass Spectrometry, BioAnalytical Team

Location:  San Rafael, California Category: Research



BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

The BioMarin Center of Technology (CoTe) is a new, centralized laboratory built around platform technologies and made available to scientists and physicians across Worldwide Research and Development (WWRD) of BioMarin. The Mass Spectrometry (MS) Core within the CoTe provides collaboration, expert advice, service, training, and open access to state-of-the-art MS technologies to the entire scientific community of WWRD. Our lab contains 16 mass spectrometers, including Orbitraps, QQQs, Q-Traps, Q-TOFs (ESI + MALDI), and GC-MS.

We are searching for a highly-motivated and independent bioanalytical scientist/mass spectrometrist with ≥4 years of experience in LC/MS-based bioanalytical method development to lead the development of a high-throughput screening program to support a range of candidate discovery projects.  This position also offers a unique career opportunity to work on the entire spectrum of a product lifecycle, from early drug discovery and non-clinical work through all stages of clinical and commercial development. The successful candidate will work directly with colleagues from the CoTe, Research, Translational Sciences, and Clinical to explore a diverse range of disease areas and treatment modalities.

This Scientist II position will report to the Director of the MS Core within the CoTe, and will have the opportunity to influence the evolution of the larger CoTe department. This person will develop and implement new MS-centric HTS platforms and interface directly with our Research colleagues to prioritize targets, set timelines, and establish phase-appropriate assay performance requirements.  They will design and execute other analytical strategies to facilitate drug discovery and development, present experiment results and interpretation in multi-disciplinary project meetings, and contribute to technical documents (e.g. assay development/characterization reports, SOPs, etc). Consideration at the Sr. Scientist I level will be given to candidates with additional, directly related experience in HTS-MS program development and/or automation. This person will also mentor junior lab staff, evaluate analytical technologies and methodologies, and contribute to scientific publications and regulatory submissions, as required. Experience with GLP and/or GCP-compliance as well as regulatory filing is desired.



  • Develop and implement an MS-centric program to support high throughput screening of various types of drug leads, including but not limited to anti-sense oligonucleotides and gene therapy vectors.
  • Develop analytical methods and workflows to quantify drugs, metabolites and biomarkers in various biological matrices. Techniques may include (but are not limited to) mass spectrometry, HPLC/UPLC, micro-flow LC and nano-flow LC.
  • Present results, conclusions, and implications to Research and Translation Sciences clients and early development teams.
  • Develop new workflows, or bring in new technology from the outside, to enhance the analytical capabilities of the MS Core or CoTe, more broadly.
  • Provide guidance and mentorship to junior lab staff, and provide training/support to ‘self-service’ users of the MS Core.
  • Prepares SOPs and other documents such as assay development reports and data reports for testing results.
  • Share responsibility for lab management and maintenance duties.
  • Serve as Bioanalytical Study Monitor for outsourced assays, participate in audits and inspections, and adhere to regulatory compliance standards, when applicable.
  • Participates in scientific meetings and produces original peer-reviewed publications.
  • Other duties as assigned.



Doctorate (Ph.D.) or M.S. degree in Biology, Chemistry or related field with a research emphasis on mass spectrometry or chromatography applications or instrument design. Established field of expertise in bioanalysis, analytical chemistry, instrumental analysis, or similar.



At least 6 years (10 years for M.S.) of hands-on experience using mass spectrometry and liquid chromatography in a biological or biochemical field. Ability to solve complex problems independently. Experience with GLP and/or GCP-compliance and regulatory filing is a plus. Excellent verbal and written communication skills are required.

Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.