Senior Research Associate

Location:  San Rafael, California Category: Research Employment Category: Fulltime-Temporary

Description

BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

Duties


BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

 

The mission of the Biology Research department at BioMarin is to conduct preclinical research evaluating potential therapeutics for severe rare diseases with unmet medical needs. Our team in the non-oncology hematology group uses state-of-the art equipment to provide proof-of-concept preclinical data in relevant disease models and data for understanding the mechanisms of action for these potential therapeutics.

We are looking for a self-motivated team player with a minimum of 4 years laboratory experience. The successful candidate will support Research & Development in generating viral and non-viral gene therapy for rare genetic diseases, and to understand drug response variabilities.

The Senior Research Associate will work closely with a team of dedicated researchers, and be committed to working in the bench, handling pre-clinical/clinical trial samples, and computational analysis.

 

Key Responsibilities

  • Careful handling and processing of tissues for high throughput sequencing, and proteomics analysis.
  • Execution of validated molecular biology assays including nucleic acid isolation (DNA and RNA), library preparation, and QC validations.
  • Develop and use varied molecular biology and analytical assays including, Real-time PCR, droplet digital PCR, Enzyme activity assays, ELISA, western blotting, etc.
  • Develop and validate new molecular assays for therapeutic development.
  • Analysis of high throughput sequencing and proteomics data.
  • The successful candidate is expected to be independent, collaborative, and promote a collegial workplace.

Skills


  • Having an Industry experience is a plus for consideration.
  • Prior hands-on experience handling biological/clinical samples.
  • Basic molecular biology (PCR, RT-PCR, western blot), and mammalian cell culture techniques.
  • Independently establishes new techniques, technologies, or methods based on evolving project demands.
  • Experience using computational tools for sequence and protein analysis.
  • Exceptional communication and organization skills.
  • Ability to effectively multitask and have a strong desire to learn and contribute.
  • Willingness to accept new responsibilities.
  • Able to integrate and assist within varying cross-functional teams.

Education


Bachelor’s degree and at least 6 years of experience; Master’s degree with at least 4 years of relevant experience.



PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.