Senior Statistical Programmer, Clinical Pharmacology

Therapeutic & Translational Research Vancouver, BC


Why Work for Us? 

Innovation. Act with Integrity. Collaboration. Embrace Diversity. Care

We come from many countries, cultures, races, ethnicities, abilities and nationalities. We bring our passions including singing, biking, swimming, dancing, cooking, volunteering, parenting, coaching and much more! We are proud of our nearly equal balance of men and women and strengthened by our non-binary and transgender team members. Every employee belongs.

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance. 

Company Description

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer.  Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates. 

Zymeworks is seeking a highly motivated Senior Statistical Programmer, Clinical Pharmacology who is looking to grow their career with our company. 

This position will report to Principal Scientist, Pharmacokinetics and will be located in either Seattle, WA or Vancouver, BC. 

About the Position

As a senior scientific programmer on the clinical pharmacology team, you will integrate pharmacokinetic (PK) drug concentration-time measures, pharmacodynamic responses, subject characteristic data, and clinical safety and efficacy information to support PK/PD and population PK modeling and simulation analysis. 

Job Description and Responsibilities

  • Overall responsibility to plan and generate analysis datasets, statistical tables, figures, and listings with supporting documentation.
  • Experience with pharmacometric approaches and direct experience with software used to support clinical pharmacology modeling and simulation (SAS, R, NONMEM, Phoenix).
  • Ability to use creative thinking and expertise to develop innovative and efficient programming solutions to analyze complex pharmacometric data.
  • Conducts quality control and quality assurance activities on datasets and reports
  • Participates when appropriate in company initiatives to improve efficiency of data management, analysis, and reporting (IT, methodology, automation, quality)
  • Works closely in teams with other statistical programmers, pharmacometricians, and drug development scientists supporting a variety of pipeline oncology projects. 


  • Expert knowledge of data preparation and programming practices (CDISC, SDTM, ADaM) to support popPK or clinical pharmacology M&S
  • SAS data management expert with experience in life-sciences and clinical trials, with emphasis on data preparation of Clinical Pharmacometrics. Familiar in working with ADaM/SDTM data formats.
  • Experience with the R software platform considered an asset.
  • Experience with relevant software and tools within the field of clinical pharmacology M&S is a plus (e.g. R, NONMEM, Monolix, Phoenix)
  • Demonstrated knowledge of clinical drug development.
  • Ability to effectively communicate and adapt to a fast paced and dynamic work environment
  • Effective organizational skills to meet timelines with multiple ongoing projects
  • Attention to detail and ability to ensure high quality of programming deliverables
  • An equivalent combination of education and experience may be considered.
  • Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.

NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.