Senior Research Associate, In Vivo Biology/Pharmacology

Multispecific Antibody Therapeutics Vancouver, BC Vancouver, BC


Description

Why Work for Us?

Innovation. Act with Integrity. Collaboration. Embrace Diversity. Care

We come from many countries, cultures, races, ethnicities, abilities and nationalities. We bring our passions including singing, biking, swimming, dancing, cooking, volunteering, parenting, coaching and much more! We are proud of our nearly equal balance of men and women and strengthened by our non-binary and transgender team members. Every employee belongs.

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Company Description

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer.  Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Zymeworks is seeking a highly-motivated professional who is looking to grow their career with our company.  

This position will report to the Group Lead, In Vivo Pharmacology and will be based in Vancouver, BC. 

As a condition of employment, Zymeworks requires all employees to be fully vaccinated against Covid-19 and provide verification of such.

Key Responsibilities

  • Applies preclinical in vivo mouse pharmacology models to enable translation of cancer therapies.
  • Handles mice (awake and/or under gaseous anesthetic, or after euthanasia) including subcutaneous, intraperitoneal and intravenous injections, frequent tumor measurements, blood and tissue collection, and regular health monitoring.
  • Prepares drugs using sterile BSL procedures for administration to mice.
  • Performs mouse study-related administrative tasks including regulatory documentation and inputting scientific data records.
  • Regularly performs mammalian tissue culture, including the maintenance of multiple tumor cell lines using sterile technique, as well as the expansion, cryopreservation and thawing of cell lines as needed.
  • Maintains high levels of productivity, organization, and teamwork in the laboratory including the use of inventory management systems.
  • Documents detailed observations, methods, raw and analyzed data and results. Explains reasons for variances. May interpret results and make recommendations on findings.
  • Maintains workspace (laboratory and animal facility rooms) and performs routine duties in order to keep areas stocked, clean, neat and in efficient operational order.
  • Effectively organizes and schedules activities in the animal facility and/or laboratory with teammates.
  • Conducts all activities in accordance with scientific standards, Canadian Council on Animal Care (CCAC) and OH&S regulations and established policies and practices.
  • Fosters effective and collaborative working relationships with fellow employees and management.

Additional Responsibilities:

  •  May conduct in vitro/ex vivo assays to facilitate mouse pharmacology model development.
  • Performs a variety of established cell-based in vitro assays for functional characterization of bispecific antibodies include pharmacokinetic and pharmacodynamic responses.
  • Regularly performs isolation and culture of lymphocyte populations from human blood or mouse organs.
  • Prepares basic written reports and analysis of experiments. Consults with others for data interpretation. Communicates results and analysis to working group.
  • Seeks to understand ongoing projects through attention to scientific literature and internally generated data.

Qualifications and Education

  • Minimum of BSc in a scientific discipline or Veterinary Technician Diploma and minimum 2 years hands-on experience in mouse husbandry and veterinary techniques, or an equivalent combination.
  • An equivalent combination of education and experience may be considered.
  • Embody and champion Zymeworks’ values: Act with Integrity. Collaborate. Care.
  • Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.

Skills and Abilities:

  • Track record of working with and direct handling of small animal models (rodents) and performing procedures associated with test article administration and sample collection.
  • Experience with mouse tumor models, including xenografts, in vitro cell culture techniques and/or immunological assays is required, and syngeneic model experience is an advantage.
  • Preparation and injection of tumor cell lines for initiating immuno-oncology models is essential.
  • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships.
  • Good organizational skills and the ability to work effectively in a high paced, fast changing environment. Results-oriented.
  • Working knowledge of regulations, standards and guidelines for care and use of vertebrate animals in research (CCAC guidelines) and animal care protocols.
  • Commitment to performing work with the highest regard for animal welfare.
  • Consistent and diligent attention to detail and excellent record keeping skills.
  • Dedicated work ethic and flexibility to work full-time alone and/or in a small team in an animal facility.

NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

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