Associate Director, PKPD and QSP

Therapeutic & Translational Research Seattle, Washington


Why Work for Us? 

Innovation. Act with Integrity. Collaboration. Embrace Diversity. Care 

We come from many countries, cultures, races, ethnicities, abilities, and nationalities. We bring our passions including singing, biking, swimming, dancing, cooking, volunteering, parenting, coaching and much more! We are proud of our nearly equal balance of men and women and strengthened by our non-binary and transgender team members. Every employee belongs. 

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Company Description

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of next-generation bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer.  Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates. 

Zymeworks is seeking a highly motivated Associate Director, PKPD and QSP who is looking to grow their career with our company.

This position will report to Senior Director, Pharmacokinetics and will be located in either Seattle, WA or Vancouver, BC.

As a condition of employment, Zymeworks requires all employees to be fully vaccinated against Covid-19 and provide verification of such.

Key Responsibilities

  • Oversee PKPD and QSP modeling and simulation activities in support of the oncology pipeline projects and platform development
  • Collaborate with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology (PKPD and QSP) to aid in target selection, target prioritization, therapeutic modality selection, protein optimization, biomarker characterization and early clinical trial design
  • Work with project team leaders to develop comprehensive criteria for decision making to portal therapeutic programs by expertise in design, execution and interpretation of quantitative models of in vitro, in vivo and FIH studies
  • Supervise a team of modelers to enable/facilitate model design, troubleshoot issues, and evaluate and provide feedback on interim and final model results/outputs.
  • Conduct data analyses requiring accuracy in experimental techniques, calculations and completeness of data and adherence to prescribed testing analyses, modeling or computation methods.
  • Identifies test methodologies, devises theories, conducts tests, reaches conclusions and recommends solutions to guide other research and development work
  • Prepares reports and presentations for internal and external stakeholders and writes/contributes to manuscripts for publication.
  • Fosters effective and collaborative working relationships with fellow employees, management and external partners. 


  • PhD in a scientific discipline (Biophysical Sciences, Molecular Sciences, Mathematical and Computational Sciences) or equivalent in engineering or a minimum of 5 years related industry experience is preferred. An equivalent combination of education and experience may be considered.
  • An equivalent combination of education and experience may be considered.
  • Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion. 

Skills and Abilities

  • Experience with interpretation of quantitative modeling to provide insight in the oncology disease area and with novel therapeutic modalities (e.g. bispecific, cytokine-fusion proteins and other targeted agents)
  • Excellent understanding of theory and principles of advanced mathematical modeling and simulation
  • Strong experience with statistical aspects of parameter estimation for complex non-linear quantitative models
  • Thorough understanding of the basic principles of pharmacokinetics (non-compartmental, compartmental, PBPK)
  • Technical expertise with modeling and simulation software for PK/PD and mechanistic QSP model building (e.g. MATLAB, Simbiology, ADAPT, Monolix)
  • Technical skill with software tools for data processing, statistics, and visualization (e.g. R, SAS)
  • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team. Ability to establish and maintain effective working relationships
  • Good organizational skills and the ability to work effectively in a high paced, fast changing environment. Results-oriented.

NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.