Research Associate II, In Vitro Biology

ADC Therapeutic Development Vancouver, BC


Why Work for Us?

Innovation. Act with Integrity. Collaboration. Embrace Diversity. Care

We come from many countries, cultures, races, ethnicities, abilities and nationalities. We bring our passions including singing, biking, swimming, dancing, cooking, volunteering, parenting, coaching and much more! We are proud of our nearly equal balance of men and women and strengthened by our non-binary and transgender team members. Every employee belongs.

We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.

Company Description

Zymeworks is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer.  Zymeworks’ suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.

Zymeworks is seeking a Research Associate II to join the In Vitro Biology group within the ADC Therapeutic Development department. The In Vitro Biology group is responsible for the in vitro functional characterization and advancement of Antibody Drug Conjugate (ADC) therapeutic candidates and platform technologies. The successful candidate will be part of a dynamic and motivated team responsible for supporting pipeline program advancement and contributing to core platform technology improvements and innovation. The candidate will be challenged to critically analyze results and contribute to the Zymeworks team effort to create clinically and commercially relevant therapeutics.

Zymeworks is seeking a highly-motivated professional who is looking to grow their career with our company. This position will report to Senior Scientist, In Vitro Biology, ADC Therapeutic Development and will be based in Vancouver, BC.

As a condition of employment, Zymeworks requires all employees to be fully vaccinated against Covid-19 and provide verification of such.

Key Responsibilities

  • Performs advanced experiments for the functional characterization of bioconjugates or ADCs for various pipeline programs, using different cell-based assays and techniques, e.g. cell growth inhibition and co-culture assays with various read-out modalities (luminescence, fluorescence, absorbance, etc.)
  • Characterizes antibodies and ADCs using flow cytometry, high throughput screening, live cell imaging, 3D tissue culture, ELISA, and other methods as required to support pipeline project advancement.
  • Contributes to experimental design and supports novel assay development by troubleshooting methods and suggesting novel and impactful changes to methods.
  • Supports mammalian tissue culture activities in In Vitro Biology group, maintaining numerous immortalized tumor and normal cell lines. Works with team to ensure cell lines are properly expanded, cryopreserved and databases updated as required.
  • Applies knowledge of scientific methodologies in conducting technically advanced analyses and data interpretation. Prepares and disseminates data presentations for group meetings, summarizing results and aids in crafting experimental outlines.
  • Adheres to Zymeworks standard procedures for generating, documenting, and archiving data, maintaining an accurate, up-to-date electronic laboratory notebook.
  • Conducts all activities in accordance with scientific standards, OS&H regulations and established Zymeworks’ policies and practices.
  • May co-author or author scientific papers.
  • Actively works to foster an environment of effective and collaborative working relationships amongst employees, management, and external partners.
  • Contributes to a safe and highly efficient laboratory environment.

Qualifications and Education

  • Requires a BSc in a scientific discipline (biology, biochemistry, microbiology, molecular biology, etc.) and a minimum of 2-3 years’ related experience.
  • Embody and champion Zymeworks’ values: Innovate, Act with Integrity, Collaborate, and Care.
  • Adhere to the highest degree of professional standards and strict confidentiality on matters that require discretion.
  • Must be able to work onsite in Vancouver, BC.

Skills and Abilities

  • Good organizational and time management skills and the ability to work effectively in a fast paced, fast changing environment.
  • Excellent interpersonal skills with the ability to work effectively and collaboratively as a member of a cross-functional team; ability to establish and maintain effective working relationships.
  • Good oral, presentation, and scientific/technical writing skills.
  • Knowledge of GraphPad and FlowJo softwares considered an asset.

Advanced knowledge and proficiency in the following techniques

  • Flow cytometry
  • High-content analysis or fluorescence imaging
  • Mammalian tissue culture
  • General knowledge of antibody and antibody drug conjugate structure/function
  • Immunological/co-culture assays considered an asset.

NOTE TO EMPLOYMENT AGENCIES: Zymeworks values our relationships with our Recruitment Partners. We will only accept resumes from those partners whom have been contracted by a member of our Human Resources team to collaborate with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.