Description

EXECUTIVE DIRECTOR, CLINICAL DEVELOPMENT

Position Overview

Sutro Biopharma is seeking an Executive Director, Clinical Development to serve as a thought partner to the VP, Clinical Development in shaping the overarching clinical strategy for its oncology portfolio. Working collaboratively with global study leads, this physician will develop clinical strategies, strengthen safety assessment, and support the execution of global clinical programs. The role is ideally suited for a physician-scientist with deep oncology expertise and prior experience in ADCs or targeted therapies. This role also requires a strong safety background, experience leading clinical studies, and deep knowledge of early development trials, together with the ability to build trusted investigator relationships and translate clinical evidence into clear recommendations.

Key Responsibilities
Clinical strategy and study leadership

• Partner with the VP, Clinical Development to evaluate portfolio opportunities, emerging risks, and development options; provide clinical and scientific perspectives that inform overarching strategy and priorities.
• Collaborate with global study leads to develop and refine clinical development plans and study strategies, integrating patient populations, dose and schedule, endpoints, biomarkers, geographic considerations, and evidence needed for key decisions.
• Apply early development expertise to first-in-human studies, dose escalation, dose optimization, and expansion cohorts; integrate emerging safety, efficacy, pharmacology, and translational data into development recommendations.
• Contribute to the design, conduct, interpretation, and communication of clinical studies, including protocols, amendments, investigator materials, and clinical study reports. Partner with study leads and Clinical Operations to address clinical issues and support study milestones.

Clinical safety and medical monitoring

• Provide strong clinical safety expertise across programs. Partner with global study leads and Pharmacovigilance to review emerging safety data, assess potential signals and benefit-risk, and recommend appropriate follow-up and risk mitigation.
• Serve as a backup medical monitor to global study leads and other designated medical monitors, providing coverage for investigator questions, eligibility assessments, medical review of adverse events, and protocol-related medical decisions.
• Support safety review meetings and clinical interpretation of adverse events and laboratory trends; help translate findings into monitoring recommendations, protocol updates, and clear communication to study teams.

Regulatory and leadership communications

• Support Regulatory Affairs, the VP, Clinical Development, and study leads in preparing clinical content for regulatory submissions, briefing documents, responses to health authority questions, and regulatory meetings; participate in interactions as appropriate.
• Help prepare Board of Directors materials and executive updates, synthesizing clinical progress, safety findings, development options, and key risks into clear, balanced presentations and recommendations.

Investigator engagement and scientific advisory

• Build and maintain relationships across the investigator network, academic centers, and external oncology experts. Travel domestically and internationally for site engagement, investigator meetings, scientific congresses, and advisory discussions as needed.
• Partner with study leads to gather investigator insights on study design, feasibility, enrollment barriers, and clinical practice, and apply those insights to clinical strategy and study execution.
• Help plan and lead scientific advisory boards and expert discussions; develop focused questions, evaluate external input, and translate recommendations into practical development options.

Collaboration and organizational contribution

• Work across Clinical Operations, Pharmacovigilance, Translational Medicine, Biostatistics, Data Management, and Regulatory Affairs to align on clinical questions, resolve issues, and support timely decisions.
• Mentor colleagues, communicate candidly, and contribute to consistent clinical development practices that support patient safety, scientific rigor, data integrity, and quality.

Qualifications

Required

Preferred

Sound exciting? Apply today and join our team!

Sutro Biopharma, Inc. encourages all colleagues to be fully vaccinated for COVID-19 prior to the first date of employment.

As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together.

We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies.    

The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma’s California based locations will be $354,000 – $30,000 (not including bonus, equity, and benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.

About Sutro Biopharma

Sutro Biopharma, Inc., is relentlessly focused on the discovery and development of precisely designed cancer therapeutics to transform what science can do for patients. Sutro’s fit-for-purpose technology, including cell-free XpressCF®, provides the opportunity for broader patient benefit and an improved patient experience. Sutro is advancing a robust early-stage pipeline of novel exatecan and dual-payload antibody drug conjugates (ADCs), coupled with high-value collaborations and industry partnerships, which validate its continuous product innovation. Sutro is headquartered in South San Francisco. For more information, follow Sutro on social media @Sutrobio, or visit www.sutrobio.com.