Senior Scientist Conjugation

Technical Operations & Process Sciences Bothell, United States


Position at Seagen

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us! 


The Seagen Conjugation Process Development group is seeking an excellent Sr. Scientist to lead antibody-drug conjugate (ADC) process development projects ranging from early-phase clinical molecules through late-stage or commercial products. The Sr. Scientist will use their expert knowledge of scientific principles and concepts to solve complex drug development problems in creative and effective ways. They will identify and champion new ideas and technologies that enhance business processes within the Conjugation Process Development group. They may supervise the activities of more junior personnel and would be responsible for driving the development of those employees. They may lead intra-department projects or initiatives involving cross-functional contributors. They will contribute toward peer reviewed publications, invention of IP, internal reports, and/or regulatory filings. 

Principal Responsibilities:  

  • Leads pre-IND and/or late-stage antibody drug conjugate (ADC) development activities 
  • May serve as functional area lead for clinical programs/inter-departmental initiatives 
  • Leads significant components of drug development or technology projects 
  • Independently designs, executes, and interprets multiple studies. Designs experiments to be carried out by others 
  • Prepares lab and pilot scale antibody drug conjugates 
  • Leads process characterization studies, risk assessment, and control strategy development for late-stage process development 
  • Able to oversee multiple development projects, including early and late-stage programs 
  • Applies practical and theory expertise of the relevant area of science, process development, and manufacturing 
  • Demonstrates good knowledge of other functional areas in Process Sciences 
  • Supports validation activities 
  • Leverages literature, ICH/Regulatory guidance, and practical experience to perform their work and influence CMC strategies 
  • Recommends and implements new technology that advances knowledge and productivity within department 
  • Motivates and supports the career development and technical growth of direct reports. Regularly meets with, sets clear goals and expectations, and provides timely feedback to direct reports 
  • Authors and reviews technical reports, manufacturing documents, regulatory submissions, and publications 
  • Presents at department, project team, and sr. management meetings. May present externally at scientific conferences 

Required Qualifications:  

  • BS. and 14+ years; M.S. and 11+ years; Ph.D. and 3+ years of industry experience 
  • Degree in chemistry, biochemistry, chemical engineering, or related field 
  • Deep knowledge of antibody or protein production and/or conjugation processes 
  • Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)  
  • Willingness to work with highly potent cytotoxic molecules 

Preferred Qualifications:  

  • Experience with ADC process development  
  • Direct experience with antibody or protein conjugation 
  • Experience with GMP manufacturing and technology transfer to manufacturing sites 
  • Proficiency with tangential flow filtration 
  • Experience with late-stage development 
  • Familiarity with CMC team function 
  • Strong knowledge of statistical software such as JMP 
  • Experience with programming languages such as Python, R, or SQL 

As t
he leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit  

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.  

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.