Associate Director Toxicology

Translational Sciences Bothell, Washington South San Francisco, California



We are seeking a toxicologist with drug development experience to join our team of nonclinical scientists. You will be part of a skilled group leading the scientific understanding of the safety of novel therapeutics (primarily biologics) in a company dedicated to finding cures to cancer.  Interpretation, integration, and assessment of the significance of data in the context of multiple other scientific investigations, both internally and externally, are critical. You will be expected to review findings from nonclinical studies in support of clinical development and will have significant autonomy to propose and drive the investigative and mechanistic understanding of these toxicities. Your communication skills at all levels of interaction must be excellent as you will work closely with colleagues within and outside of the organization. This is a pivotal role in the nonclinical sciences group, and you will be expected to contribute significantly to growing the toxicology expertise within the organization. In addition, you will serve as a nonclinical representative on project teams and may have the opportunity to serve as a research & translational sciences team lead on early projects.


Principal Responsibilities:

  • Foster continued development of the group’s research and regulatory toxicology expertise through conduct of non-GLP and GLP toxicology studies
  • Provide expertise to understand the mechanisms of toxicity observed nonclinically and/or clinically in order to drive mitigation and/or back-up strategies to minimize potential harm to patients
  • Act as a nonclinical team representative responsible for the nonclinical safety strategy of novel target/therapeutic candidates. Your ability to understand the toxicity of the platform versus target-related toxicities is key
  • Present data and interpretations in written and oral form to regulatory bodies to enable optimal clinical development and registration of novel drugs
  • Assist in developing and delivering an overarching strategy for the delivery of toxicology data, which may include internal resources and/or external partners
  • Build collaborative networks internal and external to the company to ensure rapid communication and cross-functional evaluation and investigation of emerging safety issues
  • Aid in the development of a forward-facing vision of the nonclinical sciences department, and support implementation of this vision
  • Develop strong knowledge of the basic biology of the intended target of drug candidates
  • Represent Seattle Genetics in the external scientific environment – influencing partners and regulators in a positive way


Required Qualifications:

  • 8 to 12 years of toxicology experience in a contract research organization and/or pharmaceutical/biotech setting; designing studies, interpreting data, generating reports and regulatory documents
  • Experience in nonclinical safety assessment from discovery through development, especially with biologics
  • Proven success in scientific investigation of fundamental toxicology issues, either through scientific publications or drug development experience
  • Ph.D. in toxicology, or a related field
  • Diplomate, American Board of Toxicology (or equivalent)


As the leading employer in our industry in the Pacific Northwest, Seattle Genetics is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seattle Genetics, please visit

Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.