Staff Scientist - Animal Modeling
Seattle Genetics is seeking a highly motivated, interactive, and flexible Staff Scientist to advance our development of rodent tumor models, advance in vivo technologies, and refine our outsourcing resources. Our company culture places a premium on scientific excellence, innovation, and teamwork to develop translational models that have meaningful impact in the development of biopharmaceuticals and treatment of cancer. The ideal candidate will become an integral part of the Comparative Biology Group team within Nonclinical Sciences and contribute independently to multiple projects aimed at understanding tumor biology within the context of xenograft, orthotopic, syngeneic, and novel tumor models. Additionally, he or she will apply novel in vivo strategies and technologies to advance science and biopharmaceutical development to help ensure that the safest and most effective therapeutics advance to the clinic.
- Independently plan, coordinate, execute, and analyze results of complex in vivo studies in rodent models
- Understand project strategy, drive key components forward, and propose new strategies or methods to further advance projects
- Train, advise, and consult with research staff across multiple groups on the implementation of appropriate technical procedures to meet project goals
- Develop and implement novel animal models to address research questions
- Design and conduct in vitro and ex-vivo experiments to understand the mechanism of action of therapeutic candidates
- Develop/implement operational strategies to standardize workflow and increase throughput.
- Maintain meticulous laboratory records, electronic files, and laboratory notebooks to support experimental studies
- Compile and analyze data, provide regular updates, and present results at internal and external meetings and publications
- Minimum of 10+years (BS) or 5+ years (MS) technical experience working with rodent models in a biology/biomedical (or similar) research laboratory
- High level of expertise in mouse and rat procedures including tumor implantation, tumor growth monitoring, dosing (SC, IP, IV, PO, etc.), aseptic surgery, and blood and tissue collection, handling and processing
- Solid understanding of concepts and principles of molecular, cellular, cancer, and immune biology
- Proficient in tissue culture techniques including lentiviral transduction, selection, cloning, characterization by flow cytometry
- Proficient in cell-based and ex vivo assays including cytotoxicity, bystander co-culture, cell cycle arrest, DNA damage, tumor immune cell profiling, tumor target expression
- Familiarity with commonly used software applications (Word, Excel, PowerPoint, etc.)
- Ability to troubleshoot, interpret, and summarize scientific data in an accurate, critical, and concise manner
- Ability to communicate effectively with colleagues at all levels. Excellent communication skills, both written and oral
- Must be goal-oriented with the ability to handle multiple tasks and to prioritize
- Experience in working with contract research organizations including drafting statements of work, working with Legal to draft contracts, managing timelines, and trouble shooting
As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.
Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.