Principal Scientist - Cell Death Immune Modulation

Research Bothell, United States


Position at Seagen

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us! 


Seagen is seeking a highly motivated, innovative, and collaborative Principal Scientist to lead research on immunogenic forms of cell death to guide therapeutic innovation and support the design and mechanistic understanding of our therapeutic pipeline.  In addition to leading this foundational research, this individual will also implement and democratize relevant in vitro and in vivo assays to support therapeutic design and development in collaboration with therapeutic program teams.  The ideal candidate will have a sustained record of being a creative and rigorous scientist, a team player, and an effective communicator.   

Requirements or Responsibilities: 

  • Actively design and execute in vitro and in vivo experiments to assess the underlying mechanism of action of therapeutic agents that elicit immunogenic cell death or other anti-tumor mechanisms that are immune-modulating 
  • Develop in vitro and in vivo assays and biomarkers of immune-modulating mechanisms of cell injury/death to support therapeutic innovation and development  
  • Collaborate cross-functionally with therapeutic program leads to evaluate current and new ADCs for immune modulation 
  • Devise systems to assess the combinational activity of anti-tumor immune-modulating mechanisms and other direct immune-modulating mechanisms  
  • Oral and written presentation internally and externally at scientific conferences 
  • Train, mentor, empower, and develop associates on the team 

Required Qualifications: 

  • A Ph.D. in immunology or related discipline with 5-8 years of postdoctoral experience or a B.A/B.S in immunology or related discipline with 11+ years of related laboratory experience   
  • Demonstrated experience independently designing and executing in vitro and in vivo experiments. Deep understanding of the cellular and molecular mechanisms leading to cell injury/death and impact on modulating downstream immune responses   
  • A deep understanding of the cellular immune components, effector function and/or regulation, and the use of in vivo systems to evaluate immune functions 
  • Required Technical skills: Flow cytometry, in vitro cell-based assay development with primary and immortalized cells, Luminex assays, general cell-biology/biochemistry/molecular biology techniques  
  • Excellent skills in written and oral communication, organization and multitasking, and working in a collaborative and cross-functional research environment 

Preferred Qualifications: 

  • Hands-on experience in applying biologics or small molecules to modulate the immune response is a plus 
  • Preferred skills: in vivo pharmacology experience, omics technologies 

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit  

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.  

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.