Research Associate I Cell Line Development

Technical Operations & Process Sciences Bothell, United States


Description

Position at Seagen

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us! 

Summary:  

The BioProcess and Analytical Sciences department at Seattle Genetics is seeking a highly motivated individual to work in the Cell Line Development (CLD) group. The Research Associate will support development of cell lines used to produce therapeutic proteins for clinical trials and future commercial applications while engaging cutting-edge technologies to characterize and advance our platform. The CLD team uses modern molecular biology and aseptic cell cultures techniques to create recombinant CHO cell lines for biologics production. As a key stage-gate between research and bioprocess development, CLD functionality is critical to the establishment and advancement of CMC project timelines and deliverables.  The CLD team works in a highly collaborative, cross functional CMC setting involving many functional areas. 

Principal Responsibilities:  

  • Analyze recombinant protein expression using high-throughput analytical methods 
  • Assist with ongoing cellular and metabolic profiling of antibody-producing cell lines using cell-based and protein chemistry assays 
  • Aid in the engineering of expression vectors using standard molecular biology techniques 
  • Compile and analyze data, keep accurate records of experiments and results 
  • Provide updates and present data in team and group meetings 
  • Engage in all aspects of maintaining mammalian cell lines including passaging of cells, preparation of tissue culture reagents, and helping with laboratory upkeep and restocking 

Requirements:  

  • Bachelor’s degree in Biology, Biochemistry, Bioengineering or related science major 
  • Strong organization, time management and problem-solving skills 
  • A team player with good communication skills, desire to achieve team and individual goals 
  • Working knowledge of mammalian cell culture using aseptic techniques 
  • Experience with basic molecular biology techniques: PCR, DNA cloning and sequence analysis 

Desired Skills:  

  • Experience staining and analyzing live and fixed cells using flow cytometry methods 
  • Familiarity with general protein chemistry and cell-based assays including protein extraction, western blotting, and reporter assays 
  • Basic understanding of mammalian cell biology and metabolism 
  • Relevant experience in the biotechnology industry or academic laboratory 

 

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.  

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.  

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law. 

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