Senior Scientist Cancer Target Discovery

Research Bothell, United States


Position at Seagen

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us! 


Seagen is seeking a highly collaborative Sr. Scientist with a strong background in Cancer Biology, Immunology and/or tumor microenvironment to lead research activities supporting early research programs for ADC and/or targeted therapy development. This individual will be responsible for designing and executing preclinical discovery research activities in collaboration with cross functional project teams for drug development candidates. The successful candidate will directly contribute to Seagen pipeline as a Research Lead, and it is expected to drive collaborative efforts with immunologists, cancer and system/computational biologists to establish clear go/no go criteria and advanced projects. They should have a record of being a strong scientist, team player, strategic thinker, and an effective communicator. This position will be responsible for directly mentoring and managing others including junior scientists and/or research associates.  
Principal Responsibilities: 

  • Conceptualize opportunities for therapeutic (ADC or other) development  
  • Design, conduct, and interpret experiments utilizing a diverse array of techniques aimed at identifying and characterizing tumor-selective targets and their underlying biology 
  • Leverage target biology to guide therapeutic design and identify and utilize the appropriate preclinical models for therapeutic design validation 
  • Identify relevant cancer or immunology targets to generate biological hypotheses (e.g. target characterization and drug combinations) in oncology 
  • Design and execute comprehensive experimental plans that inform and enable project progression. Will define clear go/no go criteria in alignment with overall research and corporate strategy  
  • The candidate will serve generally as a subject matter expert in cancer biology or area of immunology, stay abreast of relevant literature and act as an expert resource within research  
  • Work independently and demonstrate the ability to collaboratively contribute to projects outside their own expertise 
  • Excellent interpersonal and presentation skills 
  • Coach and mentor people for performance and scientific growth 
  • The candidate will be a creative, vocal, and enthusiastic scientist able to think and work independently, with a strong collaborative spirit 
  • May provide research support/oversight for external collaborations and/or MTAs and represent research on advisory boards 
  • Presents research at scientific conferences, key contributor to regulatory documents and peer reviewed publications, will work in close collaboration with legal to support appropriate patent filings 

Required Qualifications: 

  • PhD Cancer Biology, Biochemistry, or Immunology 
  • 2-5 years of experience leading projects/programs in a biotechnology or pharmaceutical company focused on oncology and/or immunology discovery and drug development  
  • 2-3+ years of experience supporting research for IND-track research projects and/or clinical programs 
  • Experience leading or contributing core technical expertise across multi-functional project teams 
  • Ability to identify and plan critical path experiments in alignment with team objectives 
  • Demonstrated ability to plan, manage and organize work across multiple projects 
  • Uses critical thinking to solve complex problems, address challenges, overcome obstacles and plan for the future 
  • Highly effective interpersonal skills, ability to identify and absorb critical information and convey it to relevant stakeholders 
  • Strong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences 
  • Strong collaborator with ability to function across teams and a variety of disciplines 
  • Ability to gain support and commitment for research plans using compelling rationale 
  • Ability to recognize and deliver on key department and project objectives 
  • Ability to adapt and adjust to a rapidly evolving environment 
  • Strong management and mentoring skills 

Preferred Qualifications: 

  • Knowledge of ADCs and/or therapeutic antibodies 
  • Demonstrated record of publications and/or presentations at scientific conferences 

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit  

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.  

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.