Scientist II, Applied Immunology

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company dedicated to creating treatments for diseases based on the power of the human T cell repertoire to eliminate cancer cells, target pathogens, and regulate immune function.

Repertoire’s strategy lies in understanding the immune synapse – the interaction between specific T cells and the corresponding antigen-presenting cells that dictate T cell activity.  The company’s proprietary DECODE™ technology platform, developed by Repertoire scientists, provides a comprehensive understanding of the full repertoire of interactions between T cell receptors and their antigen targets.  We believe the ability to decode these interactions represents one of the greatest opportunities for innovation in medical science.

Repertoire’s team operates from sites in Cambridge, Massachusetts and Zurich, Switzerland and uses its DECODE technology to rationally design treatments for cancers, autoimmune disorders, and infectious diseases.

Role Overview

We are seeking a motivated Scientist to join the Applied Immunology Team, which is responsible for driving innovation and early development within Repertoire’s best-in-class natural T cell therapy platform. This is an opportunity to play a central role in the development of the next generation of cancer immune medicines through the design, execution, and interpretation of experiments to enhance T cell phenotype, function, and therapeutic potency. The ideal candidate is a creative and collaborative research scientist with a record of utilizing state-of-the-art immunobiological methods to solve complex problems and a drive to lead efforts to apply immune biology principles to the development of transformational immune medicines.

Key Responsibilities

  • Lead efforts to study and enhance biological function and potency of cell therapy products through the design, execution, and interpretation of immunobiology experiments.
  • Actively contribute to cross-functional projects focused on T cell phenotype, function, and therapeutic potency through planning and hands-on execution of experiments in the areas of process biology (e.g., primary immune cell isolation and ex vivo culture systems), as well as development and/or implementation of enabling immunological characterization methods (e.g., multi-color flow cytometry and sorting, MHC/peptide tetramer analysis, ICS/ELISpot, Luminex, RNAseq, and other related immune function assays).
  • Apply an innovative approach and technical immunobiology expertise to collaborative, matrixed project teams comprising colleagues in Immunology, Cell Process & Analytic Development, and Translational Medicine to inform project strategy and drive optimization of cell therapy platforms.
  • Independently plan and execute experiments, capturing primary data and documenting work in ELN as required; review, interpret, and communicate results within cross-functional project teams; present data to internal research group, matrixed research organization groups, and scientific leadership teams
  • Demonstrate spirit of continuous learning and curiosity, as well as commitment to scientific rigor and collaboration.
  • Leverage strong interpersonal, verbal, and written communication skills.

Qualifications/Experience

  • Ph.D. in Immunology, Biology, Bioengineering, or a related field with at least 2 years of relevant industry/academic experience; Master’s degree in relevant field with at least 6 years directly relevant Immunology experience.
  • Experience in the area of T cell immunology, with a record of innovative contributions in one or more areas of interest: immune cell phenotype and function, APC / T cell interactions, immune cell multi-omics, immunopathogenesis of autoimmune disease, and/or cell therapy process biology & development.
  • Demonstrated expertise in the development and application of cellular and molecular methods to test biological hypotheses and solve problems.
  • In-depth experience with general cell biology / immunology techniques, including isolation and culture of primary cells, co-culture systems, multi-color flow cytometry, and T cell-based assays such as MHC/peptide tetramer analysis, ICS/ELISpot, Luminex, cytotoxicity, and TCR sequencing.
  • Demonstrated ability to work both independently and as an integral part of a team.
  • Demonstrated ability to problem solve through grit, creativity, implementation of enabling technologies, and leveraging of cross-functional expertise.
  • Demonstrated agility and interest to work in a fast-paced and rapidly evolving field.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.