Assay Development Research Associate/Sr. Research Associate

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a Research Associate/Sr. Research Associate to join our assay development team in Repertoire’s platform technology group.  The primary role of the position is to develop and implement molecular assays and workflows as part of our DECODE platform, which supports discovery programs and translational sciences.  We are looking for an enthusiastic team player who will thrive in an accelerated, dynamic, and highly collaborative environment.  The successful candidate will work as part of a cross-functional team of immunologists, molecular biologists, and protein scientists to develop and verify assays, explore new technologies, and drive process scale-up.

Key Responsibilities

  • Plan and execute projects and experiments with limited instruction.
  • Perform data analysis.
  • Prepare reports, presentations and updates as needed.
  • Present results to internal stakeholders across the organization.
  • Keep detailed lab notebook.
  • Identify opportunities for process improvements.
  • Evaluate new technologies for potential incorporation into our DECODE platform.
  • Support technology transfer of assays and methods.

Qualifications/Experience

  • Bachelor’s degree (or equivalent) in Genetics, Molecular/Cellular Biology, or related scientific discipline.
  • 2+ years of experience working with NGS in industry or academia.
  • Knowledge of DNA and RNA extraction and in-situ hybridization techniques.
  • Successful track record with DNA/RNAseq protocols, in particular Illumina library preparations.
  • Experience handling tissue samples including FFPE.
  • Familiarity with single cell and bulk sequencing analysis.
  • Ability to learn quickly and execute towards meaningful results.
  • The ability to prioritize and complete tasks in a timely manner.
  • Proficiency with general molecular biology approaches.
  • The ability to think critically and perform functions with minimal guidance.
  • Impeccable documentation practices and attention to detail.
  • Experience with flow cytometry and cell sorting preferred.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.