Research Associate, In Vitro Biology, Tolerance Platform

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  However, we are currently expanding our remit into other autoimmune disorders.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a highly motivated Research Associate or Senior Research Associate to join the preclinical biology team within the Tolerance Platform group, which is responsible for developing and deploying best-in-class immune modulatory therapies based on Repertoire’s proprietary immune DECODE technologies.  Working closely with a Senior Scientist, the candidate will work to develop, establish, and apply primary human cell culture methods and analytical methodologies to validate peptide/epitope targets and to assess the functionality of T cells and antigen presenting cells in the context of autoimmune disease and tolerance induction.  The candidate will also be responsible for analyzing and presenting data to their supervisor and to the team in a timely manner.  As part of a multi-disciplinary platform development team, the candidate will work closely with the in vivo pharmacology team, the nanoparticle technology team, the protein sciences team, and the discovery immunology teams to advance the development of antigen specific tolerizing therapies for autoimmune diseases.

The ideal candidate will have hands-on experience with primary immune cell culture systems and analytical assays as well as the capability and desire to learn and apply new experimental methodologies.  The candidate will be motivated by driving the generation of experimental data at the bench and will have strong interpersonal, verbal, and written communication skills that will enable them to integrate with our highly cross-functional teams.  Drive to execute, experimental rigor, and scientific curiosity are key!  The ability to work in a fast-paced environment and adapt to evolving priorities is a must.

Key Responsibilities

  • Work with the team to execute experimental projects under the supervision of scientific project leads.  Culture and maintain primary human T cell and immune cell cultures.
  • Capture primary data and document work as required in Electronic Laboratory Notebook (ELN) maintaining up to date records.
  • Analyze, summarize, and communicate data to supervisor and team.
  • Apply and expand skills with complex analytical methodologies such as multi-color flow cytometry and sorting, T cell co-culture systems, ELISpot, Luminex, and related immune assays.
  • Support general lab operations with reagent preparation, instrument maintenance, and adherence to lab safety procedures.

Qualifications/Experience

  • B.S. in Biology, Immunology, Bioengineering, or a related field.
  • Minimum of 1 year of academic or biotech/pharma laboratory experience.
  • Experience with general in vitro cell culture/immunology techniques including T cell based assays and culture of primary cell lines.
  • Experience with flow cytometry and immunoassay methodologies such as flow/FACS, ICS, ELISpot, and ELISA.
  • Strong organizational skills as well as excellent attention to detail.
  • Proven track record of being personable, energetic, accountable, and an effective communicator.
  • Must work well independently as well as an integral part of the team.
  • Ability to work in a fast-paced and quickly changing environment.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.