Research Associate/Sr Research Associate – Platform Production (DECODE Lab)

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a Research Associate/Senior Research Associate to join our Immune DECODE Lab.  The primary role of the RA/SRA is to be responsible for the production and QC of proprietary materials generated for use in our DECODE platform.  We are looking for an enthusiastic team player who will thrive in a dynamic and highly collaborative environment.  The RA/SRA will work as part of a cross-functional team of immunologists, molecular biologists, and protein scientists to successfully execute production and contribute to process scale-up.

Key Responsibilities

  • Execute a variety of protocols on the Hamilton Star liquid handler.
  • Evaluate Hamilton runs using standard protein QC assays.
  • Troubleshoot and gather any relevant data to identify issues related to production.
  • Work closely with the Automation team to sync production schedules/instruments.
  • Contribute to ongoing process improvements/expansions within the Automation team.

Qualifications/Experience

  • Bachelor’s or Master’s degree (or equivalent) in scientific discipline or a health-related field.
  • 1-5 years post B.S. experience in relevant experimental research area in industry or academia (title commensurate with experience).
  • Strong background in protein characterization and associated laboratory techniques (SDS-Page, Western Blot, Nanodrop).
  • Experience with plate-based protein and/or DNA assays (ELISA, PicoGreen, Bradford, BCA).
  • Familiarity with Liquid Handlers is highly preferred (Hamilton, Tecan, etc.).
  • The ability to prioritize and complete tasks in a timely manner.
  • The ability to think critically and perform functions with minimal guidance.
  • Impeccable documentation practices and attention to detail.
  • Excellent written and verbal communication skills.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.