Scientist I/II, Nanotech Delivery (Tolerance)

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a highly motivated Scientist I/II to work in the nanotech delivery (tolerance) technologies team, which is responsible for developing and deploying best-in-class immune modulatory therapies based on Repertoire’s proprietary immune DECODE technologies.  This is an opportunity to build and characterize a novel tolerance-inducing platform.  Working with a dedicated team of Scientists and Research Associates, the successful candidate will contribute to cross-functional efforts to formulate and analyze different classes of nanoparticles and measure their ability to modulate the immune system using both in vitro and in vivo models.  The role represents an opportunity to learn immunology, RNA biology, and autoimmune in vivo mouse models while contributing to nanoparticle formulation.  As part of a multi-disciplinary team, the candidate will work closely with the departments of in vivo pharmacology, protein sciences, antigen discovery and validation, computational sciences, and CMC development to advance this new platform through pre-clinical and clinical development.  Strong interpersonal, verbal, and written communication skills along with experimental rigor and scientific curiosity are key!

Key Responsibilities

  • Design and formulate a variety of nanoparticles to modulate the immune system.
  • Characterize these nanoparticles thoroughly with the appropriate analytical tools.
  • Collaborate with pre-clinical biology and disease area teams on using these nanoparticles using in vitro and in vivo model systems.
  • Analyze, summarize, and communicate team leadership and project teams.
  • Document work in electronic lab notebook and author project summaries as needed.
  • Provide scientific, project, and laboratory leadership to junior scientific staff. Lead by example with lab safety.

Qualifications/Experience

  • M.S. or Ph.D. in Materials Science, Chemistry, Chemical Engineering, Bioengineering, or a related field plus equivalent experience.
  • Relevant experience related to synthesis, formulation, and characterization of nanoparticles (lipid and polymeric nanoparticles) including expertise in DLS, HPLC, SEM, mass spectrometry, synthetic chemistry, and lipid characterization.
  • Subject matter expertise in nanoparticle formulations, general chemical, and materials synthesis.  Experience with mRNA/LNP technologies is a plus.
  • Subject matter expertise with analytical technologies for material and formulation characterization.
  • Knowledge of antigen presenting cell biology, APC and T cell interactions, and peptide/MHC/TCR interactions is a plus.
  • The successful candidate will be motivated by building, testing, and characterizing nanoparticles for complex biological systems as well as by working with the broader team to drive projects and programs forward.  
  • Ability to identify, troubleshoot, and solve issues associated with complex materials.
  • Strong organizational skills and excellent attention to detail.
  • Proven track record of being personable, energetic, accountable, and an effective communicator.
  • Must work well independently as well as an integral part of the team.
  • The ability to work in a fast-paced, matrixed team environment, and adaptability to evolving priorities are a must.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.