Scientist, In Vivo Pharmacology

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are looking for a highly independent and motivated Scientist to join the preclinical biology team within the autoimmune tolerance platform, which is responsible for the evaluation of novel antigen-specific therapeutics in both mouse models of autoimmune disease as well as in ex vivo human and mouse systems.  The Scientist will design and implement in vivo studies in multiple autoimmune disease systems and model systems.  Routine laboratory tasks will include establishing disease paradigms in mice, administering experimental therapies, observing and documenting the progression of disease, collecting and processing samples, isolating, enriching and culturing various subsets of immune cells, and performing downstream analysis by flow cytometry, ELISA, Luminex, and other methods.  The ideal candidate will be self-driven, confident with handling mice in an experimental setting, have an in-depth understanding of vivarium workflow, and a keen interest in immunology and disease modeling.  Understanding of T cell biology, antigen processing and presentation, and central and peripheral tolerance is critical.  The successful candidate will be an excellent written and verbal communicator, enjoy a fast-paced and fun team environment, and promote a positive work culture in the lab.  This position will interact closely with colleagues in the preclinical biology and product engineering teams. 

Key Responsibilities

  • Contribute as an active member of the cross-functional tolerance platform discovery and early development team.
  • Become a subject matter expert in one or several key areas of autoimmunity and immune tolerance.
  • Implement established in vivo immune tolerance model studies in mice.  Apply these tools to investigate the efficacy, mechanism of action, and safety of investigational therapies.
  • Devise and implement novel in vivo models to extend the scope of pre-clinical investigations in autoimmunity.  Execute proof of principle studies, validate appropriate analytics, scale up for product candidate screening.
  • Apply in vivo models for assessing pharmacokinetics, biodistribution, and safety profile of investigative therapeutic technologies.
  • Contribute to ex vivo immune cell assays including co-culture and others.
  • Maintain and implement good laboratory practices including accurate laboratory notebook systems, instrument and reagent validation, and personnel safety precautions.
  • Present data to the team, to key stakeholders, and to external audiences.

Qualifications/Experience

  • A recent Ph.D. in Immunology or an adjacent discipline as well as a strong publication record.  Postgraduate experience in academia or industry is a plus.
  • Extensive, hands on experience with mouse models of autoimmunity (e.g. EAE, IBD, T1D, model antigen-based studies) is required.
  • Proficiency with mouse pharmacology approaches: i.v., i.p., s.c. dosing, blood draws.
  • Experience with large-scale, multi-organ tissue harvest experiments for subsequent immune cell isolation and culturing or analysis is required.
  • Experience in setting up and supervising in vivo experiments executed by external parties (CRO, collaborators) a significant plus.
  • In depth experience in multi-parameter flow cytometry (surface staining, viability, proliferation, nuclear antigens, cytokines) and cytokine assays (flow, Luminex, ELISA, ELISPOT) is required.
  • Strong leadership, organizational, and communication skills
  • Must be a team player able to multitask.
  • Ability to work in a matrixed, fast paced, and quickly changing environment.
  • Ability to deliver on key milestones within defined timelines.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.