Senior Scientist, Immuno-Oncology

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company dedicated to creating treatments for diseases based on the power of the human T cell repertoire to eliminate cancer cells, target pathogens, and regulate immune function.

Repertoire’s strategy lies in understanding the immune synapse – the interaction between specific T cells and the corresponding antigen-presenting cells that dictate T cell activity.  The company’s proprietary DECODE™ technology platform, developed by Repertoire scientists, provides a comprehensive understanding of the full repertoire of interactions between T cell receptors and their antigen targets.  We believe the ability to decode these interactions represents one of the greatest opportunities for innovation in medical science.

Repertoire’s team operates from sites in Cambridge, Massachusetts and Zurich, Switzerland and uses its DECODE technology to rationally design treatments for cancers, autoimmune disorders, and infectious diseases.

Role Overview

We are seeking an innovative Senior Scientist to work in the Antigen Discovery and Validation Team, which is responsible for selecting tumor antigens that are targeted by Repertoire’s PRIME T cell therapies. The candidate will participate in understanding and improving the targeting and functionality of our PRIME T cell therapy by establishing and applying cancer-specific ex-vivo immunotherapy cell culture models that will support the selection and validation of tumor antigen targets across multiple tumor types. Both on-target and off-target (safety-related) properties of well-known and incompletely studied cancer antigens are of interest. The ideal candidate will have a proven track-record of developing novel immunology-based assays or ex-vivo cancer culture models for solving complex biological problems as well as a broad understanding of immunotherapies and their applications to cancer treatment. The position will be lab-based and as part of a multi-disciplinary team, will work closely with Computational Biology, Applied Immunology, and Discovery Immunology Teams to identify and prioritize therapeutic targets for pre-clinical development. 

The successful candidate will have the ability to independently design experiments, analyze complex data, troubleshoot technical issues, and supervise junior staff. Strong interpersonal, verbal, and written communication skills will enable them to integrate with our highly cross functional teams. Experimental rigor and scientific curiosity are key, working in a fast-paced environment with evolving priorities is a must.

Key Responsibilities

  • Lead effort to prioritize and validate tumor T cell targets for Repertoire’s Immuno-oncology program in collaboration with multiple other teams. Contribute to the understanding of biological properties of candidate targets.
  • Collaborate with the Applied Immunology team to ensure the development of robust methods for ex-vivo T cell priming to novel classes of tumor antigens.
  • Contribute to the development of functional immunological and analytical methods to characterize the response of the T cell product to cancer specific antigens, such as multi-color flow cytometry and sorting, T cell co-culture systems, MHC/peptide tetramer analysis, ELISpot, Luminex, and other related immune assays.
  • Drive innovative research into effector-target interactions in ex-vivo cell culture models of tumor immunotherapy. Establish and culture 2D and/or 3D tumor cell lines and T cell co-culture systems.
  • Implement in vitro assays to evaluate off-tumor effects of novel antigen candidates for T cell therapies
  • Independently plan and execute experimental projects with minimal supervision.
  • Review, interpret and communicate data cross-functionally with CMC, internal project teams and external collaborators
  • Establish regular interface and build strong connections with Contract Research Organizations (CROs)
  • Capture primary data and document work as required in Electronic Laboratory Notebook (ELN) maintaining up-to-date records.
  • Train research associates to accomplish program and company goals within designated timelines.
  • Analyze, summarize, and communicate data to team leadership and project teams.

Qualifications/Experience

  • Preferred candidate has a Ph.D., or equivalent in Immunology or Cancer Biology with minimum of 8+ years of relevant experience,
  • Expert in the development and application of T cell immunology or tumor biology related assays.
  • In-depth experience with general in vitro cell culture/immunology techniques including culture of primary cell lines.
  • Strong mastery of multi-color flow cytometry for T cell characterization.
  • Experience with T cell-based assays such as MHC/peptide tetramer analysis, ELISpot, Luminex, cytotoxicity, and TCR sequencing is a plus.
  • Experience with TIL isolation from tumor biopsies, culture, and phenotyping is a plus.
  • Interested in a highly adaptable, collaborative environment, responsive to evolving strategic, technical, and business priorities.
  • Excellent attention to detail, excellent written, and oral communication skills.
  • Please note that title (i.e., career level) and base salary will be based on experience for the role. 

 

Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.