Research Associate/Senior Research Associate – Immune Decode Lab

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  However, we are currently expanding our remit into other autoimmune disorders.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a Research Associate/Senior Research Associate to join our Immune Decode Lab.  The primary role of the RA/SRA is to be responsible for the preparation and quantification of next-generation sequencing to support scientific programs at Repertoire.  We are looking for an enthusiastic team player who will thrive in a fast-paced, dynamic, and highly collaborative environment.  The RA/SRA will work as part of a cross-functional team of immunologists, molecular biologists, and protein scientists to successfully execute experiments and contribute to process scale-up.

Key Responsibilities

  • Preparation RNA sequencing libraries from bulk and single-cell samples.
  • Experience with Flow Cytometry/Cell Sorting.
  • Execute and troubleshoot experiments and analysis of data.
  • Work closely with scientific staff to design and perform experiments.
  • Contribute to ongoing process improvements within the Immune Decode Lab.

Qualifications/Experience

  • Bachelor’s or Master’s degree (or equivalent) in scientific discipline or a health-related field.
  • 1-5 years post B.S. experience in relevant experimental research area in industry or academia (title commensurate with experience).
  • Strong background in molecular biology and associated general laboratory techniques (PCR, qPCR, ddPCR, nucleic acid purification).
  • Familiarity with single cell methods (eg. 10X Genomics, Smart-Seq).
  • The ability to prioritize and complete tasks in a timely manner.
  • Knowledge of genetics, immunology, and cancer biology.
  • The ability to think critically and perform functions with minimal guidance.
  • Impeccable documentation practices and attention to detail.
  • Excellent written and verbal communication skills.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.