Research Associate I/II, Cell Therapy Analytical Development

Tech Ops Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a highly motivated Research Associate II to join our growing Cell Therapy Analytical Development team.  As part of the Analytical Development team, you will contribute to the advancement of Repertoire’s DEPLOY platform: multi-antigen, cytokine-enhanced T cell therapies.  This lab-based role will perform testing on routine large-scale cell process development batches at Repertoire, as well as cell product characterization for the different programs in Repertoire’s pipeline.  The ideal candidate will collaborate effectively in a highly matrixed environment and be experienced in multi-color flow cytometry, cell culture, and immunological assays such as ELISPOT.  Organizational skills and keen attention to detail are key to succeed in this role.

Key Responsibilities

  • Execute routine testing on large scale cell culture processes (e.g., flow cytometry, antigen reactivity, and proliferation assays).
  • Design and execute experiments with guidance from direct manager.
  • Keep detailed experimental records with the use of an electronic lab notebook (ELN).
  • Maintain inventory of routinely used reagents such an antibodies and buffers as well as of cryopreserved cell samples.
  • Analyze and summarize data in a timely manner and communicate it effectively both verbally and in written form.
  • Coordinate sample transfer across different teams.

Qualifications/Experience

  • B.S. or Master’s in Bioengineering, Biological Sciences, Biology, Chemical Engineering, or equivalent with 0-2+ years of industry experience.
  • Cell culture and aseptic technique (suspension and adherent cells).
  • Multi-color flow cytometry.
  • Familiarity with Flowjo or other flow cytometry analysis software.
  • ELISPOT is a plus.
  • Excellent organizational skills.

Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.