Research Associate II, Antigen Validation, Discovery Immunology

Research & Development Cambridge, Massachusetts


Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company dedicated to creating treatments for diseases based on the power of the human T cell repertoire to eliminate cancer cells, target pathogens, and regulate immune function.

Repertoire’s strategy lies in understanding the immune synapse – the interaction between specific T cells and the corresponding antigen-presenting cells that dictate T cell activity.  The company’s proprietary DECODE™ technology platform, developed by Repertoire scientists, provides a comprehensive understanding of the full repertoire of interactions between T cell receptors and their antigen targets.  We believe the ability to decode these interactions represents one of the greatest opportunities for innovation in medical science.

Repertoire’s team operates from sites in Cambridge, Massachusetts and Zurich, Switzerland and uses its DECODE technology to rationally design treatments for cancers, autoimmune disorders, and infectious diseases.

Role Overview

We are seeking a highly motivated Research Associate II to work in the Antigen Discovery and Validation team, which is responsible for selecting the tumor antigens that are targeted by Repertoire’s autologous T cell therapies.  S/he will work at the bench to develop, establish, and apply in vitro immunological assays that will lead to the selection and validation of tumor antigen targets across patients and tumor types.  The candidate will also be responsible for analyzing and presenting data to cross-functional teams in a timely manner.  As part of a multi-disciplinary team, the candidate will work closely with the departments of Computational Biology, Cell Therapy Discovery, and Discovery Immunology to identify and prioritize therapeutic targets for clinical development.

The ideal candidate will have hands-on experience with relevant human T cell culture systems and analytical assays, and the capability and desire to learn and apply new experimental methodologies.  The Research Associate II will be motivated by driving the generation of experimental data at the bench and will have strong interpersonal, verbal, and written communication skills that will enable them to integrate with our highly cross functional teams.  Experimental rigor and scientific curiosity are key!  The ability to work in a fast-paced environment and adapt to evolving priorities is a must.  This work requires incumbents to be on-site in Cambridge, MA, 4 to 5 days per week.

Key Responsibilities

  • Independently plan and execute experimental projects under the supervision of scientific project leads. 
  • Culture and maintain primary human T cell and immune cell cultures as well as process human tumor tissues for downstream assays.
  • Apply and expand skills with complex analytical methodologies such as multi-color flow cytometry and sorting, T cell co-culture systems, ELISpot, Luminex, and related immune assays.
  • Capture primary data and document work as required in Electronic Laboratory Notebook (ELN), maintain up to date records.
  • Analyze, summarize, and communicate data to team leadership and project teams.
  • Contribute to the development and implementation of new methods and assays to characterize T cell responses to cancer-specific antigens.
  • Support general lab operations with reagent preparation, instrument maintenance, and adherence to lab safety procedures.


  • B.S. or M.S. in Biology, Immunology, Molecular Biology, Biochemistry, or a similar field.
  • Minimum of 1-2 years of biotech/pharma or academic laboratory experience; immunology/oncology experience is ideal.
  • Experience with general in vitro cell culture/immunology techniques including T cell-based assays and culture of primary cell lines.
  • Experience with flow cytometry and immunoassay methodologies such as flow/FACS (surface, intracellular, and tetramer staining), ELISpot, ELISA, and Luminex.
  • Ability to identify, troubleshoot, and solve critical issues associated with immunological methods.
  • Familiarity with molecular biology methods and single cell sequencing experience is preferred, but not a requirement.
  • Strong organizational skills as well as excellent attention to detail.
  • Proven track record of being personable, energetic, accountable, and an effective communicator.
  • Must work well independently as well as an integral part of the team.
  • Desire to work in a fast-paced and quickly changing environment.


Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.