Translational Scientist

Research & Development Cambridge, Massachusetts


Description

Repertoire Immune Medicines is hiring a Scientist to join our Translational Research group to help bridge and inform the efforts of multiple departments working on our current and next generation T-cell therapies.  A successful candidate will have a strong background in immuno-oncology with a demonstrated ability to plan, analyze, and interpret experiments independently. This candidate will have technical expertise in advanced molecular techniques such as immune-profiling, multi-color flow cytometry, and additional cell-based immunological assays, as well as the ability to perform deep literature dives in key research areas to help inform on current and future strategies and strong presentation skills to communicate such findings across different levels within the company.

 

Qualifications:

  • Position will be hired based on level of experience. MS or PhD in Immunology, Cell Biology, or related field with typically 6+ (MS), or 2+ (PhD) years of relevant experience
  • Experience in translational approaches to cell therapies is highly desired
  • The successful candidate will have experience with multi-dimensional flow cytometry, single cell RNAseq, Immunophenotyping, or other leading-edge technologies (Nanostring, Spatial Omics, Cytof)
  • Expertise in the isolation of primary human immune cells and their characterization
  • Proven ability to learn complex procedures and collaborate to solve problems
  • Proven analytical skills to interpret multi-modal data to generate key insights
  • Ability to partner with informatics and comp-sci for challenging data-analysis needs
  • Strong written and oral communication skills

 

Responsibilities:

  • Collaborate with both internal research teams, external CROs, and academic groups to advance translational immunology capabilities
  • Responsible for hands on translational research with internal and external collaborators for biomarker discovery and tumor microenvironment analyses
  • Perform experiments including analysis and interpretation of data to answer key translational questions, not limited to small scale process runs and assay development, utilizing primary human cells
  • Drive internal and external efforts to characterize immune cell populations from peripheral blood and tissue utilizing the Repertoire discovery platform
  • Drive molecular profiling of human samples to answer key questions for internal discovery and clinical program teams
  • Plan and execute complex experiments using primary cells, including interpreting primary data, troubleshooting experiments, and presenting results at team meetings.
  • Design, execute, and interpret critical experiments related to clinical responses as part of a matrix environment
  • Contribute to project management of clinical assay development, including meeting setup, facilitation, and documentation of key outputs from project stakeholders
  • Prepare, review and deliver high quality scientific presentations for internal/external use
  • Maintain an awareness of new / emerging techniques, tools and clinical findings relevant to the field.

 

The ideal candidate will possess excellent interpersonal skills and will have demonstrated a successful track record delivering against challenging commitments.  They will have a deep grounding in cutting edge science and technology and be comfortable working as part of a multi-disciplinary team and operating in a highly matrixed and fast paced environment.