Senior Research Associate - Immuno-Oncology Pharmacology

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company dedicated to creating treatments for diseases based on the power of the human T cell repertoire to eliminate cancer cells, target pathogens, and regulate immune function.

Repertoire’s strategy lies in understanding the immune synapse – the interaction between specific T cells and the corresponding antigen-presenting cells that dictate T cell activity. The company’s proprietary DECODE™ technology platform, developed by Repertoire scientists, provides a comprehensive understanding of the full repertoire of interactions between T cell receptors and their antigen targets. We believe the ability to decode these interactions represents one of the greatest opportunities for innovation in medical science.

Repertoire’s team operates from sites in Cambridge, Massachusetts and Zurich, Switzerland and uses its DECODE technology to rationally design treatments for cancers, autoimmune disorders, and infectious diseases.

Role Overview

Repertoire is looking for a highly motivated and passionate scientist with expertise in oncology and immunology to join the Preclinical Development Team. The candidate will perform in vitro and in vivo studies along with pharmacology team members to advance programs from proof of concept to IND submission. This position will work cross-functionally with protein engineering, translational biology, immunology and preclinical development scientists. The candidate will be responsible for communication of findings to the research team and active participation in project teams.This candidate will have the opportunity to work alongside a highly dynamic and collaborative team to develop an entirely new therapeutic modality.

Key Responsibilities

  • Support the platform development and candidate identification to expand our therapeutic portfolio for immuno- oncology.
  • Work closely with the autoimmune team and support all in vivo efforts
  • In vivo animal models delivering protein therapeutics and/or epitopes to modulate an immune response
  • Perform routine culturing of human cancer cells, T cells and PBMC.
  • Run in vitro assays (cell killing, cytokine secretion and proliferation)
  • Perform ex vivo assays; flow based immunophenotyping, Luminex and ELISA.
  • Independently design, perform and troubleshoot experiments.
  • Generate, analyze, and present findings in team meetings and record data in electronic notebooks in a timely manner.

Qualifications/Experience

  • Master’s degree in immunology or immuno-oncology with a minimum of 6+ years of relevant experience strongly preferred or B.S. in life sciences or related discipline with at least 8+ years of relevant industry
  • Exposure to developing and performing animal models and performing SC, IV, IP injections, tissue collections and bleeding is a plus
  • Knowledge of animal models of autoimmune disease
  • Demonstrated experience with developing and performing immune related assays including cytotoxicity, cytokine release, and proliferation
  • Proficiency with data analysis using FlowJo, Excel and GraphPad Prism
  • Experience in following IACUC protocols
  • Strong interest in T-cell biology and cancer immunotherapy
  • Experience executing, coordinating, and leading lab-based studies independently
  • Ability to multi-task with a high attention to details and able to generate high quality data
  • Proven experience in effectively communicating and collaborating to produce results with cross-functional teams

 



Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.