Research Associate / Associate Process Engineer

Tech Ops Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company dedicated to creating treatments for diseases based on the power of the human T cell repertoire to eliminate cancer cells, target pathogens, and regulate immune function.

Repertoire’s strategy lies in understanding the immune synapse – the interaction between specific T cells and the corresponding antigen-presenting cells that dictate T cell activity.  The company’s proprietary DECODE™ technology platform, developed by Repertoire scientists, provides a comprehensive understanding of the full repertoire of interactions between T cell receptors and their antigen targets.  We believe the ability to decode these interactions represents one of the greatest opportunities for innovation in medical science.

Repertoire’s team operates from sites in Cambridge, Massachusetts and Zurich, Switzerland and uses its DECODE technology to rationally design treatments for cancers, autoimmune disorders, and infectious diseases.

Role Overview

We are seeking a highly motivated Research Associate / Bio-Process Engineer to work in our Process Development group to help drive our multi-antigen specific Deep Primed™ T cell therapy platform.  We seek an enthusiastic team member who can design and execute experiments to further develop our platform of mobilizing the immune system to eradicate cancer.  Working closely within the CMC team on novel R&D programs, this individual will be involved with process characterization, development, and engineering as well as operating upstream and downstream cell processing equipment.  The ideal candidate will enjoy working in a fast-paced, highly collaborative environment, and breaking new ground in the cell therapy space.  This work requires incumbents to be on-site in Cambridge, MA, 4 to 5 days per week.

Key Responsibilities

  • Execute experiments to establish cellular process parameters and identify process scale-up activities for early-phase clinical manufacturing.
  • Provide design input and execution of well-controlled experiments to drive process improvements.
  • Isolate and maintain culture for differentiation of human progenitor cells in various conditions.
  • Perform in vitro cellular assays and analyze data to support in-process testing for process development studies and cell therapy product characterization.
  • Provide high quality cells derived from leukapheresis for process development and research project teams.
  • Collect, analyze, and present experimental data; maintain clear and complete experiment records.
  • Contribute to day-to-day lab operations including equipment/consumable purchasing, reagent inventory, and equipment maintenance, etc.
  • Collaborate with Clinical, Manufacturing, Quality, and Discovery to ensure successful completion of initial technology transfer and transfer of process improvements throughout product development lifecycle.

Qualifications/Experience

  • B.S. in Life Sciences, Chemical, or Biological Engineering or related discipline with 0 to 2 years of relevant industry experience and 1 to 2 years of lab experience.
  • Experience with mammalian cell culture techniques or primary cell culture preferred.
  • Excellent oral and written communication, highly organized with significant attention to detail.

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.