Scientist, Pharmacology & Preclinical Development

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

Repertoire is seeking a highly motivated cell biology/cellular immunology scientist to join our Pharmacology and Preclinical Development group.  The successful candidate will play a leading role in designing and implementing in vitro cell based assays, supporting a growing pipeline of projects.  The candidate will work as part of a cross-functional team of protein biochemists, immunologists, analytical scientists, and cell biologists to lead assay method development/optimization of multiple first-in-class therapeutics while contributing to the expansion of established platform technologies.

A successful candidate will have a self-starting attitude and the ability to focus and execute in a fast-paced, dynamic, and highly collaborative environment.  There is a significant opportunity for career growth and continuous learning in the highly collaborative Repertoire work environment.

Key Responsibilities

  • Develop and execute cell-based functional assays for the characterization of novel cancer immunotherapies.
  • Contribute to the mechanistic validation of first-in-class immune-modulatory therapeutics.
  • Perform quantitative analysis of antibody or protein-protein interactions.
  • Work collaboratively to build data packages across multiple related projects.
  • Independently drive development, optimization, and execution of experimental protocols.
  • Report results at team meetings.

Qualifications/Experience

Ph.D. in a relevant scientific discipline (Cell Biology/Immunology, Molecular Biology, Biochemistry, Bioengineering, or related field) with demonstrated success is required, with 0-2 years relevant post-doctoral experience.

  • Demonstrated expertise characterizing immune cell activation, evaluating drug effects in quantitative cell-based assays including method development and optimization.
  • In-depth knowledge and hands-on experience of a variety of analytical techniques such as multi-color flow cytometry, MHC/peptide tetramer analysis, ELISA, FPLC, cell counting, and cell-based assays.
  • Expertise in quantitative characterization of antibody binding, ligand-receptor interaction, receptor activation, intracellular signaling, and cellular responses a plus.
  • Demonstrated curiosity and ability to master new scientific disciplines and troubleshoot both technical and scientific problems.
  • Strong interpersonal skills including verbal and written communication skills are essential in our collaborative work environment.

Additional expertise in the following areas would be helpful:

  • Primary immune cell isolation, culture, and immune cell phenotyping
  • Antibody-based drug discovery

 

Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.