Senior RA/Associate Scientist, Immune Synapse Validation Platform

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a highly motivated, independent Senior Research Associate/Associate Scientist to join us in advancing our understanding of disease relevant immune synapses.  The successful candidate will join our TCR team which is responsible for development, standardization, automatization, and deployment of techniques for prioritization of therapeutically-relevant T cell receptors.  Data generated by the group will drive the development of therapies to make a meaningful difference for patients suffering from cancer or autoimmune diseases.

Primary responsibilities include experimental design and execution, data analysis, documentation, and verbal and written communication of results to the team and management.  A self-starting attitude and the ability to focus, attention to detail, and execute in a fast-paced, dynamic, and highly collaborative environment is a must.  There is significant opportunity for career growth and continuous learning in the highly collaborative Repertoire work environment.

Key Responsibilities

  • Generation and validation of TCRs in reporter cell lines and primary human T cells.
  • Analyze, document, summarize, and communicate data to project teams.
  • Contribute ideas for novel assays, method improvements, new instrumentation, automation, and data analysis approaches.
  • Contribute to method optimization and troubleshooting strategies in collaboration with Repertoire teams and third-party laboratories.
  • Work closely with program teams dedicated to autoimmunity and oncology projects as well as platform technology and computational biology.

Qualifications/Experience

  • B.S./M.S. in a relevant scientific discipline (Bioengineering, Cell Biology/Immunology, Molecular Biology, Biochemistry, etc.) with 12+ years relevant industry experience after receiving Bachelor’s.
  • In depth knowledge of engineered TCR systems including viral and non-viral gene transfers.
  • Working knowledge of T cell immunology including laboratory techniques related to assessment of T cell function and specificity.
  • Experience with automatization is a strong plus.
  • In depth knowledge of molecular biology, design of transgene constructs, cloning and expression in primary human cells and in cell lines desired.
  • Demonstrated ability to execute at the bench in an integrated team environment.
  • Understanding of safe lab practices, BSL requirements, and documentation using ELN.
  • Demonstrated curiosity and ability to master new scientific disciplines and troubleshoot both technical and scientific problems.
  • Strong interpersonal skills including verbal and written communication skills are essential in our ultra-collaborative work environment.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.