Scientist I

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company dedicated to creating treatments for diseases based on the power of the human T cell repertoire to eliminate cancer cells, target pathogens, and regulate immune function.

Repertoire’s strategy lies in understanding the immune synapse – the interaction between specific T cells and the corresponding antigen-presenting cells that dictate T cell activity.  The company’s proprietary DECODE™ technology platform, developed by Repertoire scientists, provides a comprehensive understanding of the full repertoire of interactions between T cell receptors and their antigen targets.  We believe the ability to decode these interactions represents one of the greatest opportunities for innovation in medical science.

Repertoire’s team operates from sites in Cambridge, Massachusetts and Zurich, Switzerland and uses its DECODE technology to rationally design treatments for cancers, autoimmune disorders, and infectious diseases.

Role Overview

We are seeking a highly motivated Scientist I to work in the Nanotech Delivery Technologies team, which is responsible for developing and deploying best-in-class immune modulatory therapies based on Repertoire’s proprietary Immune Decoding technologies.  This is an opportunity to build and characterize a novel immunomodulatory platform at Repertoire.  Working with a dedicated team of scientists and research associates, the successful candidate will contribute to cross-functional efforts to formulate and analyze different classes of nanoparticles and measure their ability to modulate the immune system using both in vitro and in vivo models.  As part of a multi-disciplinary team, the candidate will work closely with the departments of In Vivo Pharmacology, Protein Sciences, Antigen Discovery and Validation, Computational Sciences, and CMC Development advance this new platform through pre-clinical and clinical development.


The ideal candidate will have relevant experience related to synthesis, formulation, and characterization of nanoparticles (lipid and polymeric nanoparticles), including expertise in DLS, HPLC, SEM, mass spectrometry, synthetic chemistry, and lipid characterization.  The successful candidate will be motivated by building, testing, and characterizing nanoparticles for complex biological systems, as well as by working with the broader team to drive projects and programs forward.  Strong interpersonal, verbal, and written communication skills along with experimental rigor and scientific curiosity are key!  The ability to work in a fast-paced, matrixed team environment, and adaptability to evolving priorities are a must.

Key Responsibilities

  • Independently design and formulate a variety of nanoparticles to modulate the immune system.
  • Characterize nanoparticles thoroughly with the appropriate analytical tools.
  • Develop novel formulations and implement new processes for formulation design.
  • Lead and execute studies to optimize LNPs to improve their organ-specific delivery and stability.
  • Establish methods to study the stability of mRNA LNPs.
  • Collaborate with preclinical biology and disease area teams on using these nanoparticles using in vitro and in vivo model systems.
  • Analyze, summarize, and communicate team leadership and project teams.
  • Document work in electronic lab notebook and author protocols, SOPs, and project summaries as needed.
  • Provide scientific, project and laboratory leadership to junior scientific staff. Lead by example with lab safety.

Qualifications/Experience

  • Ph.D. in Materials Science, Chemistry, Chemical Engineering, Bioengineering, or a related field.
  • Subject matter expertise in peptide / protein nanoparticle formulations, general chemical, and materials synthesis. 
  • Prior experience with liposomes or mRNA LNP technologies (T-mixing, microfluidics) preferred.
  • Prior experience in analytical technologies for material / formulation characterization (HPLC/UPLC, UV-Vis, fluorescence spectroscopy, CE) preferred.
  • Familiarity with scale-up/process development of mRNA LNPs is a plus.
  • Knowledge of antigen presenting cell biology, APC / T cell interactions, and peptide/MHC/TCR interactions is a plus.
  • Ability to identify, troubleshoot, and solve issues associated with complex materials.
  • Strong communication and organizational skills, excellent attention to detail.
  • Proven track record of being personable, energetic, accountable, and an effective communicator.
  • Must work well independently as well as an integral part of the team.
  • Ability to collaborate in a dynamic and fast-paced environment.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.