Senior Director, Head of Cell Process Development

Operations Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  However, we are currently expanding our remit into other autoimmune disorders.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

The Senior Director, Head of Cell Process Development will lead the technical staff within the Cell Process Development organization and be part of the Technical Operations leadership team.  This senior role will be responsible for the development and technology transfer of Repertoire’s cell manufacturing processes.  This position will collaborate closely across several functions including Research, Technical Operations, and Regulatory, as well as with external contract manufacturing organizations.  The ideal candidate will have demonstrated experience in cell processing development, technology transfer, and CMC product development.  This position will report into the Head of Technical Operations at Repertoire.

Key Responsibilities

  • Experienced leader with demonstrated ability to develop, optimize, and trouble-shoot cell manufacturing processes.
  • Provide technical leadership to scientist and engineering staff in support of cell therapy process development, technology transfer, and related GMP manufacturing activities.
  • Evaluate and implement automated and closed cell processing technologies and improvements.
  • Lead cross-functional initiatives with a broad impact and scope to the organization.
  • Develop and maintain strong internal partnerships with cross-functional colleagues.
  • Authors and reviews technical documents including internal technical reports as well as regulatory sections related to cell process development and manufacturing processes.
  • Delivers high impact technical findings and concepts to senior leaders within the organization.
  • Up to 10% travel to contract manufacturing sites.

Qualifications/Experience

  • MS/PhD degree in Biochemical Engineering, Bioengineering or related field with 12 plus years’ experience in a biotechnology industry. A minimum of 5 years’ experience in cell process development/manufacturing science.
  • Proven leadership and track record of leading technical and cross functional teams as part of CMC product development.
  • Proven experience with process technical transfer, technical operations, and lifecycle management.
  • Direct experience with cGMPs in a cell therapy manufacturing environment.
  • Excellent oral and written communication skills.
  • Experience hiring, managing, developing, and mentoring technical staff in a technical operations environment.
  • Knowledge of the current regulatory and technology trends required. 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.