Senior / Research Engineer, Analytical and Process Development

Research & Development Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a highly motivated Senior / Research engineer for the tolerance technology platform team, which is responsible for developing and deploying best-in-class immune modulatory therapies based on Repertoire’s proprietary immune decoding technologies. This is an opportunity to work on an early discovery project to build and characterize a novel immunomodulatory platform.  Working with a dedicated team, the successful candidate will help create and analyze mRNA constructs and work on process improvements.  Opportunities to innovate include removing immunogenic impurities to produce highly immune-silent mRNA constructs, optimize processes for scale and robustness, and build a pipeline to regularly deliver these constructs internally at Repertoire.  As part of a multi-disciplinary team, the candidate will work closely with the departments of nanoparticle technology, in vivo pharmacology, protein sciences, antigen discovery and validation, computational sciences and CMC development to advance this new platform through preclinical and clinical development.

The ideal candidate will have relevant experience related to preparative and analytical separations of biological materials for both production and characterization, as well as experience with mRNA synthesis or other enzymatic reaction systems.  The successful candidate will be motivated by creating highly active therapeutic molecules for further characterization, as well as by supporting ongoing research activities within the autoimmune tolerance team.  Working with the broader team, they will drive projects and programs forward from discovery to preclinical to IND enabling studies.  Strong interpersonal, verbal, and written communication skills along with experimental rigor and scientific curiosity are key!  The ability to work in a fast-paced, matrixed team environment, and ability to adapt to evolving priorities are a must.

Key Responsibilities

  • Collaborate with a team to design and optimize the production, biochemical analysis and purification of mRNA constructs.
  • Collaborate with preclinical biology and disease area teams on characterizing purified constructs in vitro and in vivo.
  • Optimize and innovate processes for in vitro production and purification of mRNA for discovery and therapeutic applications.
  • Ensure supply of in vivo grade mRNA to the tolerance team and throughout Repertoire.
  • Analyze, summarize, and communicate to team leadership and project teams.
  • Document work in electronic lab notebook and author project summaries as needed.

Qualifications/Experience

  • BS or MS in Chemistry, Chemical/Bioengineering, or a related field.
  • 3-8 years of biotech/pharma experience post degree.
  • Experience with analytical and preparative separations including HPLC, CE, and FPLC.
  • Experience scaling and optimizing enzymatic reactions and purifications.
  • Experience with LC-MS, MALDI and/or ESI MS is a plus.
  • Strong organizational skills and excellent attention to detail.
  • Must work well as an integral part of the team.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.