Research Associate I, Cell Analytical Development

Operations Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease. The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science. Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform. The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine. Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors. In the field of autoimmunity, Repertoire is using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes. The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a highly motivated, independent Research Associate to join our growing Cell Therapy Analytical Development team.  As part of the Analytical Development team, you will contribute to the advancement of Repertoire’s DEPLOY platform: multi-antigen, cytokine-enhanced T Cell Therapies.  This lab-based role will interface with multiple teams to develop improved analytics for our cell therapy products, as well to coordinate testing on routine cell process development batches.  The ideal candidate will be proficient in multi-color flow cytometry, in vitro cell culture assays, and will have familiarity with biochemical analytical techniques such as ELISA and Luminex.  Organizational skills, as well as an effective communication style are key to succeed in this role.

Key Responsibilities

  • Design and execute experimental projects under the supervision of direct manager and in collaboration with the team.
  • Execute routine testing on cell process runs (e.g. flow cytometry, ELISA).
  • Keep detailed experimental records with the use of an electronic lab notebook (ELN).
  • Analyze, synthesize, and communicate data to the team.
  • Coordinate sample transfer across different teams.
  • Maintain inventory of routinely used reagents such an antibodies and buffers.

Qualifications/Experience

  • B.S. in bioengineering, biological sciences, biology, chemical engineering, or equivalent, with 0-2 years of industry experience.
  • Cell culture and aseptic technique (suspension and adherent cells).
  • Multi-color flow cytometry. Intracellular staining is a plus.
  • Familiarity with Flowjo or other flow cytometry analysis software.
  • Biochemical analytical techniques, such as ELISA, LUMINEX, or Western Blot are desired, but not required.
  • Excellent oral and written communication skills.
  • A desire to learn new analytical techniques, and the ability to adapt to evolving priorities.

Repertoire is committed towards social responsibility and developing an inclusive culture. Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.