Process Engineer

Tech Ops Cambridge, Massachusetts


Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens, and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

The role will be responsible for the development and optimization of Repertoire’s PRIME multiclonal T cell manufacturing process.  The position will collaborate closely with external manufacturing organizations and process development colleagues to troubleshoot and further advance and optimize the process.  The successful candidate should have experience in cell therapy process development, tech transfer and manufacturing, and be able to work highly independently in an accelerated environment.  Proven excellence in technical problem solving, project management, and communication is a must.

Key Responsibilities

  • Execute experiments to establish cellular process parameters and identify process scale-up activities to support clinical manufacturing.
  • Utilize manufacturing process knowledge and investigation skill sets to troubleshoot, identify and resolve manufacturing issues, improve process operations, and affect positive change.
  • Provide design input and execution of well-controlled experiments to drive process improvements.
  • Collect, analyze, and present experimental data; maintain clear and complete experiment records.
  • Contribute to day-to-day lab operations including equipment/consumable purchasing, reagent inventory, and equipment maintenance, etc.
  • Collaborate with manufacturing, analytical development, and quality to ensure successful completion of technology transfer and transfer of process improvements to external contract manufacturing organizations.


  • M.S./B.S. in Life Sciences, Chemical or Biological Engineering, or related discipline with 3-5 years of relevant industry experience in cell therapy process development and/or manufacturing.
  • Experience with aseptic processing, mammalian cell culture, cell or gene therapy manufacturing, and cell isolation.
  • Working knowledge of analytical testing techniques and immunology, especially T cell biology, is preferred.
  • Excellent communication and interpersonal skills.
  • Highly organized with immense attention to detail.


Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, we believe that our work requires the creativity and ingenuity of a diverse workforce, and we are committed to pursuing that in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and act as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.