Research Associate, Antigen and Product Discovery

Biotechnology Cambridge, Massachusetts


Description

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company working to unlock and direct the remarkable power of the human immune system to prevent or treat cancer, as well as autoimmune and infectious disease.  The company is founded on the belief that the repertoire of T cell receptor (TCR)-antigen codes that drive health and disease represents one of the greatest opportunities for innovation in medical science.  Repertoire scientists created and developed the DECODE and DEPLOY suite of technologies, which allow in-depth characterization of TCR-antigen pairs, and the ability to rationally design and develop novel targeted immune medicines.

From its sites in Cambridge, Mass., and Zurich, Switzerland, Repertoire’s team of more than 120 is creating a new category of immune medicines enabled from its DECODE discovery platform.  The company’s first product in the clinic is a novel multiclonal T cell therapy consisting of T cells derived from the peripheral blood, activated against a curated set of antigens and armed with a proprietary cytokine.  Repertoire is in clinical-stage immuno-oncology development today, targeting metastatic solid tumors.  In the field of autoimmunity, Repertoire is currently using its proprietary platform to discover novel epitopes and TCRs from patients with type 1 diabetes.  However, we are currently expanding our remit into other autoimmune disorders.  The company is also using its DECODE platform to discover infectious disease antigens and responding T cell clones.

Role Overview

We are seeking a highly motivated Research Associate to work in the Antigen and Product Discovery team, which is responsible for selecting the tumor antigens that are targeted by Repertoire’s PRIME T cell therapies. The Research Associate will work at the bench to develop, establish, and apply in vitro immunological assays that will lead to the selection and validation of tumor antigen targets across patients and tumor types.  The candidate will also be responsible for analyzing and presenting data to cross-functional teams in a timely manner.  As part of a multi-disciplinary team, the candidate will work closely with the departments of computational biology, cell therapy discovery, and discovery immunology to identify and prioritize therapeutic targets for clinical development.

The ideal candidate will have hands-on experience with relevant human T cell culture systems and analytical assays, and the capability and desire to learn and apply new experimental methodologies.  The Research Associate will be motivated by driving the generation of experimental data at the bench, and will have strong interpersonal, verbal, and written communication skills that will enable them to integrate with our highly cross functional teams.  Experimental rigor and scientific curiosity are key!  The ability to work and adapt to evolving priorities is a must.

Key Responsibilities

  • Independently plan and execute experimental projects under the supervision of scientific project leads.  Culture and maintain primary human T cell and immune cell cultures.
  • Capture primary data and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
  • Analyze, summarize, and communicate data to team leadership and project teams.
  • Apply and expand skills with complex analytical methodologies such as multi-color flow cytometry and sorting, T cell co-culture systems, ELISpot, Luminex, and related immune assays.
  • Contribute to the development and implementation of new methods and assay to characterize T cell responses to cancer-specific antigens.
  • Support general lab operations with reagent preparation, instrument maintenance, and adherence to lab safety procedures.

Qualifications/Experience

  • B.S. or M.S. in Biology, Immunology, Molecular Biology, Biochemistry, or a similar field.
  • Minimum of 1-2 years of biotech/pharma or academic laboratory experience; immunology/oncology experience is ideal.
  • Experience with general in vitro cell culture/immunology techniques including T cell based assays and culture of primary cell lines.
  • Experience with flow cytometry and immunoassay methodologies such as flow/FACS, ICS, ELISpot, ELISA, Luminex, and cytotoxicity.
  • Ability to identify, troubleshoot, and solve critical issues associated with immunological methods.
  • Familiarity with molecular biology methods is preferred but not required.
  • Strong organizational skills with excellent attention to detail.
  • Proven track record of being personable, energetic, accountable, and an effective communicator.
  • Must work well independently as well as an integral part of the team.
  • Ability to work in a fast-paced and quickly changing environment.

 

Repertoire is committed towards social responsibility and developing an inclusive culture.  Much as the power of the immune system lies in the diversity of T and B cells, our work requires the creativity and ingenuity of a diverse workforce.  We believe in actively pursuing equity in all facets of the work experience at Repertoire.  We will continue to educate ourselves about the inequities and barriers present in our society and take action as a company where we can make a difference.

Repertoire is proud to be an Equal Opportunity Employer.