Research Associate, Antigen and Product Discovery

Biotechnology Cambridge, Massachusetts


Description

About Us:
We are Repertoire Immune Medicines – a Flagship Pioneering company working to unleash the remarkable power of the human immune system. We seek to harness the intrinsic ability of T cells to prevent and cure disease. Our mission is a challenging one, requiring a complex and multi-dimensional approach that integrates cutting-edge biology and sophisticated, novel technologies. We stand ready to meet this challenge with our unique platforms, world-class team and unparalleled network of researchers, clinicians, academics and entrepreneurs.

Position Overview:
We are seeking a highly motivated Research Associate to work in the Antigen and Product Discovery team, which is responsible for selecting the tumor antigens that are targeted by Repertoire’s PRIME T cell therapies. The Research Associate will work at the bench to develop, establish and apply in vitro immunological assays that will lead to the selection and validation of tumor antigen targets across patients and tumor types.  The candidate will also be responsible for analyzing and presenting data to cross-functional teams in a timely manner.  As part of a multi-disciplinary team, the candidate will work closely with the departments of Computational Biology, Cell Therapy Discovery, and Discovery Immunology to identify and prioritize therapeutic targets for clinical development.

The ideal candidate will have hands-on experience with relevant human T cell culture systems and analytical assays, and the capability and desire to learn and apply new experimental methodologies.  The Research Associate will be motivated by driving the generation of experimental data at the bench, and will have strong interpersonal, verbal and written communication skills that will enable them to integrate with our highly cross functional teams.  Experimental rigor and scientific curiosity are key!  The ability to work in a fast-paced environment and adapt to evolving priorities is a must.

Key Responsibilities:

  • Independently plan and execute experimental projects under the supervision of scientific project leads.  Culture and maintain primary human T cell and immune cell cultures.
  • Capture primary data and document work as required in Electronic Laboratory Notebook (ELN), maintaining up to date records.
  • Analyze, summarize and communicate data to team leadership and project teams.

 

 

  • Apply and expand skills with complex analytical methodologies such as multi-color flow cytometry and sorting, T cell co-culture systems, ELISpot, Luminex, and related immune assays.
  • Contribute to the development and implementation of new methods and assay to characterize T cell responses to cancer-specific antigens.
  • Support general lab operations with reagent preparation, instrument maintenance, and adherence to lab safety procedures.

 

Minimum Qualifications:

  • BS or MS in Biology, Immunology, Molecular Biology, Biochemistry, or a similar field
  • Minimum of 1-2 years of biotech/pharma or Academic laboratory experience; immunology / oncology experience is ideal.
  • Experience with general in vitro cell culture / immunology techniques, including T cell-based assays, and culture of primary cell lines.
  • Experience with flow cytometry and immunoassay methodologies such as flow/FACS, ICS, ELISpot, ELISA, Luminex, cytotoxicity.
  • Ability to identify, troubleshoot and solve critical issues associated with immunological methods
  • Familiarity with molecular biology methods is preferred but not required
  • Strong organizational skills, excellent attention to detail.
  • Proven track record of being personable, energetic, accountable, and an effective communicator.
  • Must work well independently as well as an integral part of the team.
  • Ability to work in a fast-paced and quickly changing environment.