Senior Accountant

Finance & Accounting San Diego, California



  • Pre-IPO, clinical stage biotech with lead asset in Ph 1 and potential for first-in-class mechanism
  • First precision medicine approach to GI therapeutics, with platform attracting strong partners
  • Global exclusive license to Cedars-Sinai’s GI biobank and bioinformatics platform
  • Fully capitalized with top-tier investor syndicate

Prometheus is a pre-IPO biotechnology company pioneering a precision medicine approach to the discovery, development, and commercialization of novel therapeutic and companion diagnostic products for the treatment and diagnosis of inflammatory bowel disease (IBD). The company's precision medicine platform, Prometheus 360, combines proprietary bioinformatics discovery methods with one of the world's largest gastrointestinal bioinformatics databases to identify novel therapeutic targets and develop therapeutic candidates to engage those targets. Prometheus is a spin out of Cedars-Sinai Medical Center and partners with the hospital system for its biospecimens, clinical data, and bioinformatics.

The company is led by an exceptional management team bringing deep experience in GI and autoimmune therapies. CEO Mark McKenna joined in 2019 to refocus the organization around a precision therapeutics strategy after orchestrating a successful turnaround effort at Salix Pharmaceuticals. Mark and the executive team are guided by Prometheus’ board of directors, led by Chairman Tachi Yamada, M.D., and a scientific advisory board composed of key opinion leaders in IBD, including Stephan Targan, M.D., William Sandborn, M.D. and Dermot P. McGovern, M.D., Ph.D.


The company recently secured a $130 million Series D financing with a top-tier syndicate and is attracting best-in-class collaboration partners such as Takeda and Dr. Falk. With a lead therapeutic program in Phase 1 studies and a robust emerging pipeline, the company is seeking a best-in-class immunologist to lead all of Prometheus’ preclinical development efforts and be accountable for delivering a sustainable pipeline of drug candidates, from target validation through IND submission.


This position will be responsible for preparing journal entries, reconciliations and analysis to support the monthly close process as well as performing the accounts payable function. Duties include maintaining prepaid and other amortization schedules, cash and banking, full-cycle accounts payable, as well as additional accounting and analysis procedures as assigned. Assists in the preparation and review of monthly internal financial reporting and monthly and quarterly financial reporting to management.      



  • Perform monthly balance sheet account reconciliations and preparation of the majority of the month end close journal entries for the Company
  • Evaluates existing processes and recommends opportunities for improvements in efficiency, accuracy, and timeliness
  • Research variances to budget and trend fluctuations to identify errors and/or explain variances to management
  • Preparation of monthly bank reconciliations for all bank accounts
  • Assist in cash management forecasting by estimating weekly cash needs and proposing bank transfers when necessary
  • Assist in the preparation and review of the monthly and quarterly financial packages for management
  • Responsible for creating and updating purchase orders, assigning appropriate account coding, and obtaining proper signature authority for all purchase requisitions
  • Perform full-cycle accounts payable function including invoice entry, executing check runs, and preparing wire transfers for payment
  • Maintain organized record keeping for all vendors, including obtaining W-9s for new vendors
  • Lead the annual 1099 reporting process
  • Responsible for preparing detailed schedules and support as requested by outside auditors in conjunction with quarterly and annual financial reviews and audits
  • Participates in proactively identifying, assessing and implementing prevent and detect controls and participating in compliance with all internal control related requirements
  • Applies principles of accounting and maintain the financial records in compliance with US GAAP, Company policies and internal controls


This job has no supervisory responsibilities.


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Strong organizational and time management skills are necessary.


Position generally requires a BA/BS degree in Finance/Accounting with 5 or more years of related experience in general ledger maintenance, journal entry preparation, balance sheet reconciliations and knowledge of basic accounting.  Strong skills in Microsoft Excel and Word required. Experience in the biotechnology industry is preferred. Experience with Quickbooks is required. 


Intermediate skills: Ability to read and interpret documents such as safety rules, operating and maintenance instruction, and procedure manuals. Ability to write routine reports and correspondence. Must be able to effectively interact in a team environment. Verbal and written communication and interpersonal skills are also critical. Will interact with all levels of the organization. Ability to effectively present information and respond to questions from all levels of the organization.


Intermediate Skills: Ability to add, subtract, multiply and divide in all units of measure, using whole numbers, common fractions and decimals. Ability to compute rate, ratio and percent to draw and interpret bar graphs. Ability to calculate figures and amounts such as discount, interest, commissions, proportions, percentages. Ability to apply concepts of basic algebra.


Intermediate skills: Ability to apply common sense understanding to carry out instructions furnished in written, oral, or diagram form. Ability to deal with problems involving several concrete variables in standardized situations.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.