Scientist, Process Chemistry
Description
ORIC Pharmaceuticals, Inc, is a clinical stage oncology company dedicated to improving patients’ lives and focused on developing treatments that address mechanisms of therapeutic resistance. We are seeking a highly motivated process research and development chemist with a proven record of sustained laboratory achievement and innovation to join our growing CMC group at ORIC Pharmaceuticals. The successful candidate will report to the Director of Process Chemistry and will be responsible for the following.
- Design, planning, and execution of multi-step experimental studies to provide safe, efficient, robust and scalable processes.
- Independently use PAT and analytical tools and interpret data to gain reaction understanding.
- Share literature and available resources to support relevant precedent for process research.
- Perform experiments and interpret data (calorimetry, TGA, DSC) to safely scale reactions.
- Author development reports and technical packages, and author/review relevant sections in health authority filings (including INDs, NDAs, annual reports, and any other regulatory interactions) and patents.
- Prepare presentation materials and clearly communicate research results to manager, and at internal/external meetings.
- Working cross-functionally with Analytical and Formulations Development colleagues.
- Tech transfer to CMO and scale-up of chemistry, including supporting GMP manufacture.
Requirements
- PhD in relevant field (or evidence of equivalent industry experience) with 0-2 years of experience in the field of synthetic organic chemistry.
- Proven track record for solving process chemistry problems, including identification, optimization, and characterization of robust and scalable synthetic routes.
- Firm understanding of mechanistic organic chemistry.
- Working understanding of analytical tools used in process development (e.g., DSC, TGA, DVS, HPLC, NMR, KF, PLM, XRPD).
- Able to work as part of a team with strong interpersonal skills. Excellent oral and written communication skills. Succinct but thorough communication skills with attention to detail, analytical/critical thinking, and data organization, presentation, and inference.
- Demonstrated passion, curiosity, and enthusiasm in pursuing ideas and solutions despite challenges.
- Demonstrated initiative, ownership, problem identification, problem solving, and strategic thinking.
- Experience writing research reports and detailed reaction procedures.
- Experience in writing and reviewing lab notebook and reports.
- Demonstrated ability to work independently and efficiently in a collaborative, fast-paced, integrated, multidisciplinary team.
- Consistent demonstrated high performance, above and beyond the minimum expectations and needs.
- Scientific excellence as demonstrated by publications, presentations, and leadership/engagement in the scientific/professional community.
- Awareness and understanding of ICH, GMP, and regulatory guidances that are important to consider in new drug development.
- Excellent oral and written communication skills. Succinct but thorough communication skills with attention to detail, analytical/critical thinking, and data organization, presentation, and inference.
The anticipated salary range for candidates who will work in our South San Francisco location is between $121,000-$160,000. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etc.
ORIC Pharmaceuticals, Inc. is an equal opportunity employer. ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristic.