LIMS PROGRAMMER

Information Technology & Systems Cambridge, MA


Description

Company Profile

Gritstone Bio is a public, next-generation personalized cancer and infectious immunotherapy company. Gritstone brings together distinguished scientific founders, an experienced and diverse management team, a seasoned and successful board of directors and deep financial backing to tackle fundamental challenges at the intersection of cancer genomics, immunology, and immunotherapy design. The company’s goal is to identify and deploy neoantigens for novel treatments of cancer and infectious diseases. In addition to neoantigen therapy development, Gritstone is leveraging its unique antigen discovery platform to define targets for shared antigen immunotherapies, which would provide an opportunity to treat even more patients.

Position Summary

Gritstone bio, Inc. is seeking a talented and highly motivated LIMS Programmer to join the LIMS team. The LIMS Programmer will be responsible for the support and development of Gritstone’s Laboratory Information Management Systems (LIMS): (1) SAPIO Exemplar and (2) LabVantage Pharma. The role will serve as the primary technical contact for Sapio Exemplar and will additionally provide backup remote support for LabVantage. The role is high visibility and high customer-touch, so an upbeat, positive attitude combined with a passion for delivering first in class IT services is essential to success. This role will reside at our Cambridge, MA facility. The successful applicant is independent, a great communicator, and can thrive working on a cross-site team.

Job Duties & Responsibilities

  • Collaborate with Process Development, Manufacturing and Quality to support, administrate, and develop capabilities for Gritstone’s Laboratory Information Management System (LIMS) and associated applications. 
  • Work with key stakeholders to gather requirements for potential or implemented features to refine and improve functional requirements and integration requirements. 
  • Evaluate new feature releases from the vendor in lower instances (DEV and UAT) to identify applicability to current processes for continuous improvement. 
  • Translate business and internal stakeholder requirements into clear technical product requirements and specifications.
  • Triage issues as they arise and manage the LIMS backlog based on business value, time and other dependencies as needed.
  • Create & coordinate validation activities and deliverables such as standard operating procedures and validation documents (URS, FRS, IQ/OQ/PQ protocols)
  • Ensure backlog content and prioritization is aligned with larger strategic objectives.
  • Lead integration of LIMS with laboratory equipment, analysis tools and batch records.
  • Develop integration architecture to enable streamlined integration for supporting opportunities for turnaround time reductions.
  • Respond rapidly to requests from scientists and provide ad hoc support for LIMS workflows and sample tracking.
  • Perform configuration of LIMS system and integration of laboratory equipment.
  • Provide primary technical support for our end users of LIMS in a GxP environment.
  • Ensure changes to LIMS conforms with the Change Management processes.

Education & Qualifications

Qualifications

  • Bachelor’s degree in Computer Science, Life Science, Engineering, or related field
  • 5+ years of experience in biotechnology or biopharmaceuticals including 3-5 years working with LIMS (Sapio LIMS and Lab Vantage LIMS or equivalent) and working knowledge of 21CFR Part 11
  • Experience with integration of LIMS systems with laboratory equipment/instrumentation.
  • Basic understanding of system administration, permissions strategy, or computer system validation
  • Experience interacting with software management tools in Bitbucket, Confluence and Atlassian tools.
  • Experience with software development and testing.
  • Experience with a scripting language such as Java, javascript and/or python
  • Familiarity with relational databases and Structured Query Language (SQL)
  • Experience writing User, Functional, and Configuration Specifications in a regulated environment
  • Experience with computer systems validation
  • Experience with Next Generation Sequencing a plus
  • Experience with:
    • developing formal technical specifications
    • lab information technology systems architecture and integration
    • Experience with developing software integrations between systems.