Medical Science Liaison, [New York City (5 boroughs, North East Corner Jersey)]

Medical Affairs


Job Title: Medical Science Liaison, [New York City (5 boroughs, North East Corner Jersey)]

Epizyme, Inc. is a fully integrated, commercial-stage biopharmaceutical company committed to its mission of rewriting treatment for cancer and other serious diseases through novel epigenetic medicines. In addition to an active research and discovery pipeline, Epizyme has one U.S. FDA approved product, TAZVERIK® (tazemetostat), for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma (ES) who are not eligible for complete resection; adult patients with relapsed or refractory follicular lymphoma whose tumors are positive for an EZH2 mutation as detected by an FDA-approved test and who have received at least 2 prior systemic therapies; and adult patients with relapsed or refractory follicular lymphoma who have no satisfactory alternative treatment options. These indications are approved under accelerated approval based on overall response rate and duration of response. Continued approval for these indications may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). The company is also exploring the treatment potential of tazemetostat in investigational clinical trials in other solid tumors and hematological malignancies, as a monotherapy and combination therapy in both relapsed and front-line disease settings. By focusing on the genetic drivers of disease, Epizyme seeks to match medicines with the patients who need them. For more information, visit


Epizyme has assembled a world-class team with a passion for scientific innovation and a commitment to developing novel epigenetic therapies.  Join a dynamic, diverse and fun work environment consistent with Epizyme’s cultural attributes for success: camaraderie, collaboration, disciplined, innovative, openness, patient-focused and resilient. 


At Epizyme, the role of the Medical Science Liaison (MSL) is to:

  • Establish and maintain peer-to-peer relationship with leading clinicians and researchers
  • Ensure that Epizyme products are utilized safely
  • Serve as scientific resource within the medical community

Key Responsibilities

  • Ensure that all activities and interactions comply with Epizyme business guidance, policies, SOPs, Office of Inspector General (OIG), Accreditation Council for Continuing Medical Education (ACCME), and the Pharmaceutical Research and Manufacturers of America (PhRMA) guidelines and policies
  • Establish and maintain credible peer-to-peer scientific interactions with national and top regional opinion leaders as well as clinicians and researchers in relevant therapeutic areas
  • Serve as primary resource for clinical and scientific information related to Epizyme’s science, research, and products
  • Present accurate, fair balanced scientific information to medical and scientific communities, including at medical conferences and Epizyme sponsored meetings
  • Respond appropriately to requests for scientific or medical information about marketed or investigational products utilizing approved materials
  • Provide detailed clinical data on Epizyme products to payer and access organizations upon request
  • Serve as a liaison for the submission, review, execution, and completion of Investigator Sponsored Trials (IST) proposals
  • Actively support research objectives for company sponsored trials
  • Contribute to projects and initiatives within a matrix environment
  • Work collaboratively and compliantly with internal stakeholders and Epizyme field employees across the organization
  • Communicate practice or research-related insights and information compliantly to internal and external teams
  • Develop and maintain awareness of the competitive landscape and communicate trends to internal stakeholders
  • Provide input in to the development of and ensure the appropriate execution of Medical Affairs strategic plans and initiatives
  • Participate in executing MA strategy at medical conferences, includes attending and summarizing relevant sessions, coordinating coverage of booth activities, and proactively facilitating thought leader interactions
  • Accomplish goals with high degree of integrity and within established regulatory, legal and compliance guidelines


Education and Requirements

  • Health sciences advanced or doctoral degree, such as a PharmD, MD, or PhD highly preferred. PA, MSN, NP, DNP accompanied by previous pharmaceutical industry or clinical research experience in the area of Oncology/Hematology will be considered
  • Clinical or prior pharmaceutical industry experience in therapeutic area of oncology and/or malignant hematology
  • 5 years clinical or pharmaceutical experience with a minimum of 2 years of experience in field medical or medical affairs
  • Understanding of local medical practice and clinical decision making as it pertains to patient care
  • Ability to interpret scientific data and translate this information to meet educational, clinical, and research needs
  • Understanding of the design and execution of research studies
  • Exemplary communication and presentation skills
  • Ability to think strategically and collaborate effectively
  • Ability and willingness to travel a minimum of 60% of workdays required, including overnights and occasional weekends (e.g. medical conferences)


Epizyme, Inc. is a vibrant, entrepreneurial EEO employer committed to a diverse and dynamic workplace.