Senior Director Medicinal Chemistry

Chemistry New York, New York Hayward, California


Company Description

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.


The Senior Director of Medicinal Chemistry is central to our Drug Development pipeline.  Reporting to the Vice President, Chemistry, you will assist in building Eikon’s Medicinal Chemistry teams.  

About You 

You’re a motivated and seasoned drug hunter who is interested in using innovation to push the boundaries of traditional drug discovery process.  You are a hands-on leader who loves to solve difficult problems and are not discouraged by challenges.  You’re well-organized, detail oriented, and take pride in your ability to rapidly analyze situations and judicious decisions.  You’re collaborative by nature with uncompromising integrity.  You’re conscientious and pay almost obsessive attention to detail, documentation and organization are second nature.  You are excited about being a foundational member of a rapidly growing team.  

What You’ll Do 

  • Lead cross-function drug discovery team(s) collaborating with biologists, chemists engineers and pharmacologists 
  • Support advancement of drug discovery projects from inception to IND 
  • Contributing to the success our projects by guiding junior team members in the hit ID and beyond; including providing strategic oversight of other programs through leaders on your team 
  • Provide leadership to optimize our drug discovery pipeline and creation of new capabilities, including defining the scientific priorities to align with corporate goals 
  • Manage intern and external team of synthetic chemists, cultivating an open and collaborative culture and providing scientific insights and mentorship to young scientists on the team 
  • Collaborate with Medicinal Chemists, Computational Chemists, DMPK specialists, Pharmacologists, Biologists and other key functions to support the advancement of our Drug Discovery portfolio 
  • May serve as proxy for the VP of Chemistry 


  • Ph.D. in Chemistry or related discipline with at least 15+ years of industrial experience in drug discovery 
  • Deep expertise in small molecule medicinal chemistry (structure-based and/or pharmacophore-based drug design, synthetic organic chemistry, ADME/DMPK optimization) 
  • Demonstrated track record of success in leading small molecule drug discovery from hit ID to IND submission 
  • Proven track record of supervising Ph.D. level scientists to high levels of productivity, including improving skills and knowledge through mentorship and focused development activities 
  • Capability to manage cross functional drug discovery teams
  • Exceptional problem-solving skills including developing creative and innovative solutions
  • Extensive experience in driving external chemistry teams at CRO's 
  • Strong leadership skills with excellent interpersonal skills, including outstanding written, verbal and presentations skills

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:​

  • 401k plan with company matching​
  • Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)​
  • Mental health and wellness benefits​
  • Weeklong summer and winter holiday shutdowns​
  • Generous paid time off and holiday policies​
  • Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies ​
  • Enhanced parental leave benefit​
  • Daily subsidized lunch program when on-site​

The expected salary range for this role is $226,000 to $260,000 depending on skills, competency and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

In accordance with the Company’s duty to provide and maintain a safe workplace, the Company requires all employees to be Fully Vaccinated with one of the FDA approved COVID-19 vaccines, which includes those vaccines that have received the FDA’s emergency use authorization. You will be expected to be Fully Vaccinated as of your Start Date. If you believe that you are exempt from this requirement under an applicable law or regulations, including Americans with Disabilities Act and California’s Fair Employment and Housing Act, you will need to contact the Company’s Human Resources group. For purposes of this section, Fully Vaccinated means (i) the completion of the vaccination regimen as approved by the FDA (by way of example, 2 doses of the Pfizer or Moderna vaccine and 1 dose of the Johnson and Johnson vaccine), and (ii) timely receiving booster vaccination, as recommended by the Centers for Disease Control and Prevention.

We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.