Scientist 2, In Vivo Pharmacology

Pharmacology New York, New York


Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.


The Scientist 2, In Vivo Pharmacology will play a pivotal role in the design and execution of complex in vivo studies to support the development of novel drug candidates be highly skilled in establishing animal models of disease and subsequently performing a range of studies assessing efficacy, pharmacokinetics / pharmacodynamics, phenotyping and toxicology.

About You

You enjoy playing a pivotal role in the design and execution of in complex vivo studies to support the development of novel drug candidates. You enjoy working in a collaborative and dynamic environment, contributing to the advancement of cutting-edge therapies and helping to shape the future of medicine.

What You’ll Do

  • Independently develop in vivo pharmacology studies to assess the PK, target engagement and therapeutic efficacy of candidate compounds. These studies may be performed in a variety of animal models of cancer, inflammatory disease or neurodegenerative disease, as dictated by target biology.
  • Independently perform in vivo experiments, including dosing, sample collection, and data analysis, while adhering to experimental protocols.
  • Work with Contract Research Organizations to execute complex PK/PD and efficacy/toxicology studies to expand the capabilities and throughput of the Pharmacology group.
  • Analyze and interpret experimental data, draw meaningful conclusions, and represent the Pharmacology group function while working closely with wider project teams and management to advance projects.
  • Collaborate closely with colleagues in pharmacology, biology, chemistry, and other departments to support integrated drug discovery efforts.
  • Prepare and maintain detailed experimental records and study reports in accordance with company policies and regulatory requirements.
  • Continuously seek opportunities to enhance experimental techniques and contribute to the development of new methodologies.
  • Maintain a strong commitment to safety practices and contribute to the development of safety protocols for in vivo experiments.


  • Postdoc fellowship or Ph.D. plus 2 years of relevant experience; or Master's plus 12 years of relevant experience; or Bachelor's plus 14 years of relevant experience.
  • Experience in establishing complex animal models of cancer, inflammatory or neurodegenerative diseases, including measurement of disease progression and therapeutic efficacy.
  • Expertise in dosing/compound administration via multiple routes (PO, IV, IP and SQ) and blood and tissue collection at in-life and terminal timepoints.
  • Experience in the design and execution of complex in vivo studies through CROs, including careful alignment and oversight of study methodology and data/sample collection.
  • Proficiency in cell biology, aseptic cell culture and ex vivo tissue processing.
  • Strong written and oral communication skills, with the ability to present data effectively to multidisciplinary project teams.
  • A collaborative mindset, with experience in the management and/or mentorship of junior scientists that enables an effective team-oriented environment.
  • Strong analytical and problem-solving skills to troubleshoot experimental challenges.
  • Familiarity with IACUC protocols and regulatory considerations related to in vivo pharmacology research.
  • Willingness to learn and adapt to new techniques, technologies, and therapeutic areas.

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

  • 401k plan with company matching
  • Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
  • Mental health and wellness benefits
  • Weeklong summer and winter holiday shutdowns
  • Generous paid time off and holiday policies
  • Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
  • Enhanced parental leave benefit
  • Daily subsidized lunch program when on-site

The expected salary range for this role is $117,000 to $135,000 depending on skills, competency, and the market demand for your expertise.

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

In accordance with the Company’s duty to provide and maintain a safe workplace, the Company requires all employees to be Fully Vaccinated with one of the FDA approved COVID-19 vaccines, which includes those vaccines that have received the FDA’s emergency use authorization. You will be expected to be Fully Vaccinated as of your Start Date. If you believe that you are exempt from this requirement under an applicable law or regulations, including Americans with Disabilities Act and California’s Fair Employment and Housing Act, you will need to contact the Company’s Human Resources group. For purposes of this section, Fully Vaccinated means (i) the completion of the vaccination regimen as approved by the FDA (by way of example, 2 doses of the Pfizer or Moderna vaccine and 1 dose of the Johnson and Johnson vaccine), and (ii) timely receiving booster vaccination, as recommended by the Centers for Disease Control and Prevention.

We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.