Senior Manager, Systems Engineering

Engineering Hayward, California


Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets. 


The Senior Manager, Systems Engineering will have a key role in defining and developing the instrument system that powers Eikon’s drug discovery pipeline. We seek a goal-oriented and collaborative engineer with a background and expertise in opto-mechanical or opto-electrical systems.  As a key member of a dynamic, multidisciplinary project team, the successful candidate will work with multiple stakeholders to define and implement an instrument that meets the required system performance. 

About You

You are an adventurous, passionate, and creative engineer eager to apply your talents to empower a new way of discovering medicines in a highly interdisciplinary biopharmaceutical environment. You are excited about the challenges of developing cutting-edge hardware from the ground up to enable novel technologies and solve real-world problems, and you will bring to these challenges enthusiasm, high energy, intellectual curiosity, and technical excellence.

What You’ll Do 

  • Work with stakeholders (customers, other cross-functional groups) to develop system-level requirements. 
  • Define specifications of system-level performance and verification or production tests to assure quality. 
  • Implement system-level tests. 
  • Working with stakeholders to develop sub-system requirements. 
  • Perform (or work with others to perform) system-level modeling and simulation where necessary. 
  • Support system-level integration.
  • Guide and contribute to cross-functional efforts that affect system performance.  For example:  calibration, firmware, software integration. 
  • Drive system bring-up, including debug, validation and system-level production tests. 
  • Manage optical/photon, power, thermal budgets for the system.
  • Define or support qualification testing of the system. 
  • Create and maintain design documentation where appropriate: requirements documents, traceability or compliance matrices, test plans, etc. 
  • Participate in or drive sub-system and system design reviews. 
  • Support triage and debug of system issues in the field, after production release.


  • B.S. or M.S. in systems design, electrical, optical, mechanical or closely related field with 8+ years of industry experience or Ph.D. with 5+ years of industry experience. 
  • 2+ years of experience directly managing people. 
  • Proven track of developing opto-mechanical or electro-mechanical systems (for example, in camera, LiDAR, metrology and instrumentation, drone, automotive applications).
  • Experience in requirements gathering and system specification. 
  • Record of working cross-functionally. 
  • Familiarity with system design best practices, instrumentation, measurement and diagnostic tools, design of experiments, and statistical data analysis. 
  • Some scripting language or instrumentation software ability (e.g., LabView or Python).
  • Some proficiency in analysis (e.g., using Python or MATLAB).
  • Self-driven, and able to work with minimal supervision. 
  • Some experience with imaging, for example with cameras, sensors or detectors. 
  • Some proficiency in design simulation software (e.g., Zemax). 
  • Experience designing products for volume production. 
  • Familiarity with the following applications: 
    • Single molecule or single particle detection and/or tracking. 
    • Super-resolution microscopy. 
    • Light sheet microscopy. 
    • TIRF microscopy.

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:

  • 401k plan with company matching
  • Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
  • Mental health and wellness benefits
  • Weeklong summer and winter holiday shutdowns
  • Generous paid time off and holiday policies
  • Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
  • Enhanced parental leave benefit
  • Daily subsidized lunch program when on-site

The expected salary range for this role is $174,000 to $200,000 depending on skills, competency, and the market demand for your expertise. 

Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.

In accordance with the Company’s duty to provide and maintain a safe workplace, the Company requires all employees to be Fully Vaccinated with one of the FDA approved COVID-19 vaccines, which includes those vaccines that have received the FDA’s emergency use authorization. You will be expected to be Fully Vaccinated as of your Start Date. If you believe that you are exempt from this requirement under an applicable law or regulations, including Americans with Disabilities Act and California’s Fair Employment and Housing Act, you will need to contact the Company’s Human Resources group. For purposes of this section, Fully Vaccinated means (i) the completion of the vaccination regimen as approved by the FDA (by way of example, 2 doses of the Pfizer or Moderna vaccine and 1 dose of the Johnson and Johnson vaccine), and (ii) timely receiving booster vaccination, as recommended by the Centers for Disease Control and Prevention.

We are currently not accepting any new third-party agencies or firms at this time. Please do not forward unsolicited agency resumes to our website, employees or Human Resources. Eikon Therapeutics will not pay fees to any third-party agency or firm associated with unsolicited resumes.