Sr. Clinical Biomarker Scientist #161

Research & Development Cambridge, Massachusetts


About Repertoire:

Repertoire Immune Medicines is pioneering molecular immunology by enabling new understandings of immune cell biology that will redefine the definition and treatment of immunological diseases. We are leveraging novel proprietary technologies to develop first-in-class precision immune modulator therapeutics that control the immune system with pinpoint accuracy, targeting the specific drivers of disease.

Repertoire Immune Medicines offers the challenge and opportunity to work at an innovative early-stage company with rapid and nimble growth, combining near stage development candidates with a sustainable pipeline for long terms success. Repertoire Immune Medicines is poised to emerge as category defining company in immunology — one that premier scientists and industry leaders feel is the ‘holy grail’ of understanding and treating immunological diseases. The company is driven to discover and fully develop novel immune modulatory therapeutics that extend and improve the lives of individuals with a broad range of serious and potentially devastating diseases.


The Clinical Biomarker Scientist will coordinate interactions between project teams, assay specialists, CRO's, PM Clinical Laboratories, and internal research efforts.

They will collaborate with research and clinical colleagues to develop and defend scientifically rigorous translational and exploratory biomarker strategies that assess signs of pharmacology, proof of mechanism, establish early signs of efficacy, enable proof of concept studies, and generate an understanding of the variability in patient response.

The Sr. Scientist is responsible for ensuring a timely delivery of internally or externally generated biomarker data for analysis. They will work with translational and clinical teams to interpret biomarker results in the context of the clinical study. The ideal candidate will be a subject matter expert in working with clinical pathologists and interpreting immunohistochemistry (IHC) results of patient samples. For the time being, IHC is outsourced, but there may be an opportunity to build internal capabilities as Repertoire continues to grow.

A successful candidate will communicate and lead within a team-oriented, matrix organization, multitask/prioritize multiple projects, and leverage information from a variety of sources to deliver effective, fit for purpose biomarker strategies, quality data, and interpretation of biomarker results to drive clinical development at Repertoire.


• Minimum of 5+ years of drug discovery/development experience within the pharmaceutical / biotech industry .

• In depth experience in various assay techniques including: Flow Cytometry, ELISA and ELISpot

• Assay development and/or experience running functional immunoassays is a requirement.

• Must be very comfortable with cell culture and working with human samples.

• Experience in immuno-oncology, inflammation and immunology is a plus.

• Experience managing internal and/or external clinical pathology workflows and vendors is a plus.

• Proven ability to effectively work within a matrix teams made up of research, technical, and clinical colleagues.

• Demonstrated ability to manage and contribute effectively to multiple projects at once.

• Ability to deliver on key milestones within defined timelines.

• Must be a team player.

• Degree in Life Science field required, PhD is preferred.