Director, Computational Biology
Description
CARGO Therapeutics is a pioneering clinical-stage biotechnology company dedicated to revolutionizing cell therapy. We leverage innovative technologies with a commitment to advancing therapeutic outcomes for a wider patient population while fostering a culture where individuals can thrive both personally and professionally.
We are seeking a talented and motivated Director of Computational Biology to join our dynamic team. The multifaceted role will focus on enabling cell therapy-related multivariate data analysis across functions. In this role, the candidate will contribute to building an infrastructure that facilitates the engineering and curation of diverse datasets. Close collaboration with team members who generate data at CARGO will be necessary to develop strategies for automating data pull-through for downstream analysis. As the usability and accessibility of data are established, the candidate will also leverage their expertise in data analysis, bioinformatics, and computational biology to generate insights that support critical objectives at CARGO.
You will oversee the implementation of rigorous quality control measures to ensure the integrity and reliability of the data used for analysis. Additionally, you will develop strategies to mitigate potential biases and confounding factors in the data, ensuring that the conclusions are robust and actionable.
As a self-starter, you will collaboratively drive projects forward and proactively seek opportunities for innovation and improvement to advance our cell therapy efforts at CARGO. You will be a critical individual contributor with the chance this role may grow into leading a team in the future. This role has the potential to shape understanding of patient response to cell therapy and influence how CARGO develops more sophisticated therapies in the future, helping to provide more patients with access to curative therapy.
WHAT YOU’LL DO AT CARGO THERAPEUTICS
- Establish strong partnerships with the IT and Data Science teams to develop and manage data infrastructure, including database architecture, data storage, and security protocols.
- Maintain proficiency in utilizing Azure or AWS cloud computing environment for data analysis and management, ensuring integration with existing infrastructure and workflows
- Collaborate closely with cross-functional teams (research, manufacturing, clinical, data science) by providing guidance on data generation and curation to enable subsequent pull through and data science analyses.
- Partner with the biostats team to develop strategies for multi-variate analyses that incorporate clinical outcomes into data sets.
- Utilize advanced statistical and computational methods to analyze large-scale datasets generated from research screening efforts, identifying key trends, patterns, and potential biomarkers.
- Develop and implement robust data analysis pipelines and algorithms to streamline data processing, quality control, and visualization in research.
- Contribute and potentially initiate the use of innovative technologies such as AI, Machine Learning, LLM.
- Integrate emerging technologies and methodologies in genomics, bioinformatics, and data science fields, into existing workflows and advise teams on how to incorporate.
- Effectively communicate findings and insights through presentations, reports, and publications, fostering a collaborative and data-driven culture within the organization.
THE RIGHT STUFF: REQUIRED EXPERIENCE & QUALIFICATIONS
- Master's or Ph.D. degree in bioinformatics, computational biology, computer science, statistics, or a related field with 3+ post-graduate years of experience.
- Familiarity with next generation sequencing is a plus (sample preparation, library generation, etc). Guide teams on preferred methods for high quality data generation.
- Proficiency in programming languages commonly used in data analysis, such as Python or R, as well as experience with bioinformatics tools and packages.
- Strong understanding of statistical methods, machine learning techniques, and data visualization principles, with the ability to apply them to biological datasets.
- Familiarity with cloud computing platforms, particularly Azure (or AWS), for data analysis and management, as well as experience working in a Linux environment.
- Excellent interpersonal and communication skills, with the ability to collaborate effectively with cross-functional teams and stakeholders.
- Proven track record of independently driving projects from conception to completion, with a focus on delivering actionable insights and solutions.
- Prior experience in cell therapy or immunology research is a plus, but not required.
ABOUT CARGO THERAPEUTICS
CARGO Therapeutics is engineering best-in-class CAR T-cell therapy to overcome resistance to cancer treatment and address barriers to access so that more patients may benefit from potentially curative therapies. CARGO is on a mission to outsmart cancer by advancing a new generation of best-in-class chimeric antigen receptor (CAR) T-cell therapies. Despite advances made by commercially available autologous CARs, these treatments are curative for fewer than half of all cancer patients. In addition, far too many patients are unable to access these potentially curative therapies due to other challenges, including manufacturing, supply constraints, slow turnaround time and reimbursement hurdles. The team at CARGO is intensely focused on pursuing novel solutions to achieve better cancer treatment outcomes and experiences.
Our founders are pioneers and world experts in CAR T cell therapy, and we have built a team with experience and success developing, manufacturing, launching, and commercializing oncology and cell therapy products. CARGO Therapeutics colleagues share a passion to help others thrive. We are tenacious in the relentless pursuit of our mission, and we innovate to change the game for the patients we serve.
Join us to help make a difference!
EEO & EMPLOYMENT ELIGIBILITY CARGO Therapeutics, Inc. is committed to building a diverse, equitable, and inclusive company. We provide equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status. CARGO Therapeutics, Inc. also complies with all applicable national, state, and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requires of applicable law.