Postdoctoral Researcher - Zhou lab

Postdoc & Scientists Novato, California


The Buck Institute has an opening for a Postdoctoral Researcher to study protein folding problems during stress and cellular aging in the Zhou lab. The Zhou lab uses budding yeast as the main model organism to research the principles of protein folding and how this process is affected by environmental stress and the aging process, as well as how the protein folding problems feedback to cellular aging. Budding yeast is an ideal model to study how mother cells age and how daughter cells reset their aging clock; both fates happen at the same time along the axis of asymmetric cell division.

We use multiple cutting-edge imaging methods, high-throughput screening, biochemistry, bioinformatics, and machine learning to systematically address the response of cellular proteome towards stress and aging. We also design and engineer new tools to solve the problems we face. As protein folding problems are featured and conserved in aging and many age-related diseases, including neurodegenerative diseases, our strategy is to take advantage of the high-throughput platforms in budding yeast and use the novel mechanisms revealed by yeast projects to guide further exploration in other animal models (e.g. fruit fly) for aging and age-related diseases. We follow basic questions and use unbiased screens to find answers and candidate proteins/genes, which are followed in detail to highlight the molecular mechanisms and gain insight into the principle of cell biology of proteostasis. The Postdoctoral Fellow is encouraged to finish 1-2 projects and publish high profile papers within 5 years and take the projects to his/her own lab in the future.


  • Ph.D. or M.D. degree in biology or related fields
  • Published research in peer-reviewed journals
  • Interest in proteostasis and cell biology
  • Previous research experience in cell biology or biochemistry is preferred
We will apply genetics, cell biology, proteomics, biochemistry, imaging and bioinformatics to solve protein folding and aging–related questions. This is a young laboratory and we are a group of exciting young researchers trying to establish a new research program related to aging. Cool discoveries and enjoying science are what we value the most.


Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent, non-profit institution located in Marin County, CA, with the goal of increasing human healthspan, or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target aging—the number one risk factor for diseases including Alzheimer’s, Parkinson’s, cancer, macular degeneration, heart disease, and diabetes—the Buck seeks to help people live better longer. We are an equal opportunity employer and strive to create an atmosphere where diversity of identity, experience, and background are welcomed, valued, and supported. Candidates who contribute to this diversity are strongly encouraged to apply.

The Buck Institute has an excellent postdoctoral research program. We offer competitive salaries, excellent benefits, a dynamic work environment, and new state-of-the-art facilities.


Please submit your CV and a cover letter indicating your past research experience, future plans, and specific questions related to protein folding and aging that you would like to pursue in the lab.