Scientist 1, Neuroscience Cell Biology

Location:  San Rafael, California Category: Research

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Description

Who We Are

BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.

Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities.

Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best – people with the right technical expertise and a relentless drive to solve real problems – and create an environment that empowers our teams to pursue bold, innovative science. With this distinctive approach to drug discovery, we’ve produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options.

About Worldwide Research and Development

From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.

The Neuroscience Research group at BioMarin is seeking a Scientist 1 with experience in utilizing iPSC and other relevant culture systems to investigate neurological disease mechanisms and advance novel treatments.

The Scientist 1 in Neuroscience Cell Biology will join and assist a team of neuroscience-focused cell biologists in advancing early-stage therapeutic programs targeting the underlying genetic causes of neurological diseases.  Employing cutting-edge in vitro approaches, he/she will assist in the development of novel, advanced cellular models of human disease in order to screen therapeutic compounds, and to identify, optimize and progress therapeutic leads.  In doing so, the Scientist 1 will establish themselves as a thought leader on method development and work diligently across functions to contribute to diverse areas such as biomarker identification, functional assay development and patient-specific disease modeling. 
The successful candidate will ideally have a strong background in neuroscience, electrophysiology and/or microscopy, cell and molecular biology, and iPSC cell culture.  He/she will have excellent interpersonal skills and a strong track record of utilizing collaboration to advance therapeutic programs.  Depending on experience level, the candidate will have the opportunity to lead early-stage therapeutic programs.  The candidate will interact with the Head of Neuroscience, Director of Cell Biology in Neuroscience, and Research and Early Development Team to provide critical updates on the Neuroscience portfolio and specific programs.
RESPONSIBILITIES:
  1. Establish in vitro screening platforms and disease models for neurological indications
    • Assist in the development of cellular screening platforms for lead identification and optimization
    • Contribute to the establishment of cutting-edge iPSC disease models for in vitro proof-of-concept studies
    • Evaluate complex new methods and culture systems, identify new areas requiring method improvement and adapt existing methods or develop new ones with direct input and supervision from a manager
  2. Identify and optimize lead compounds for early-stage neuroscience programs
    • Promote the identification of lead compounds utilizing cellular screening platforms
    • Execute experiments to understand molecular and cellular mechanisms underlying therapeutic efficacy, variability, and durability
    • Utilize and optimize technical strategies to profile drug candidates including high-content imaging (immunofluorescence, calcium imaging) electrophysiology, MEA and metabolic profiling
  3. Cross-team collaboration and engagement, data analysis and organizational skills
    • Depending on experience, potentially act as project lead for early-stage therapeutic programs
    • Committed to overcome challenges and ability to troubleshoot
    • Ability to solve complex scientific and technical issues independently
    • Contribute to scientific publications and regulatory submissions as required
    • Perform quantitative analysis within and across multiple experiments, interpret results and provide feedback on implications for program progression
    • Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
    • Excellent written and verbal communication skills
    • Contribute to productive cross-functional collaborations both within and external to BioMarin
    • Thoroughly record and document experimental methodology and results
Education & Experience Level:
  • PhD in neuroscience, biophysics, cell biology, biochemistry or related field
  • At least 0-2 years of relevant postdoctoral or industry research experience with a track record of productivity and high-impact publications
 



Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.

Equal Opportunity Employer/Veterans/Disabled

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

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