Senior Research Associate

Location:  San Rafael, California Category: Research Employment Category: Fulltime-Temporary

Description

BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

The Department of Protein Science is seeking to hire a highly motivated individual at the Senior Research Associate level to work at the interface between the protein sciences team and an early-stage in vivo research team, evaluating potential therapeutics for rare genetic disease indications. Applicants should have experience in basic histologic techniques and protein biochemistry. Candidates with experience performing protein purification/characterization as well as in situ hybridization assays, imaging and confocal microscopy are encouraged to apply. The ideal candidate is highly motivated, tech savvy, a critical thinker, and able to work both independently as well as in a team environment. In addition, the candidate should possess excellent analytical, organizational and communication skills.

Duties
Developing and executing qPCR, RT-qPCR and ddPCR assays.
Developing and performing immunohistochemical and in situ hybridization assays•
Performing basic histologic techniques (including but not limited to): fixation, embedding, sectioning and staining
Design, execute, interpret experimental results with documenting work in Benchling.
Design primers and probes for qPCR, RTqPCR and ddPCR assays
Prepare slides, propose solutions and present results at project team meetings.
Identify and implement new technologies or improved approaches in gene therapy.


Skills
Protein purification utilizing either Akta Pure or Avant platforms
Familiar with Unicorn and ChemStation instrument software.
Analytical protein biochemistry methodology--SDS-PAGE, Western Blotting, ELISA.
Epifluorescence and confocal microscopy•
Image analysis
Assay development
Proficient with Image analysis software – Visiopharm, ImageJ, etc.


Education
Bachelor’s degree in Biology or a related scientific field and at least 6-8 years of relevant
experience or Master's degree with at least 4-6 years of relevant experience.

We are an equal opportunity employer and all qualified applicants will receive consideration for
employment without regard to race, color, religion, gender, gender identity, sexual orientation,
national origin, disability status, protected veteran status, or any other characteristic protected by
law.
 
PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.