Research Associate II / Senior Research Associate I, Biology Research
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.
BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.
The mission of Biology Research is to conduct preclinical translational research evaluating potential therapeutics for severe rare diseases with unmet medical needs. We provide proof-of-concept preclinical data in relevant disease models and understanding of mechanisms of action for these potential therapeutics.
The research associate will partner closely with a team of scientists from Biology Research to provide technical assistance and support for research projects. He/She will primarily be involved in the development and optimization of molecular assays to characterize and understand the mechanism of actions of AAV-based gene therapy constructs. In particular, the candidate will contribute to the understanding the molecular mechanisms mediating the long term expression pattern of Roctavian and other liver-directed AAV gene therapy in mouse, monkey, dog, and human.
Secondly, the candidate will support to develop in vitro model systems for human diseases and perform in vitro assays for proof-of concept studies.
- Develop and perform molecular assays to characterize the vector genome structures in model systems and in human liver biopsy samples.
- Proactively troubleshoot technical issues and recommend potential corrective actions based on personal observations and literature searches.
- Develop new techniques or brings in new technology to enhance the analytical capabilities of the group.
- Record and notebook-keeping.
- Present data and participate in discussion in group meetings, department meetings, and Early Development team meetings as necessary.
- Participate in external scientific meetings and contribute to original peer-reviewed publications.
- Prepare SOPs and other reports and documents to support nonclinical and clinical programs and associated regulatory submissions. This includes qualification protocols, qualification reports, memoranda, and data reports for testing results.
- Share responsibility for lab management duties.
Techniques may include:
- Experience with basic molecular biology (molecular cloning, qPCR and ddPCR) and biochemistry assays (enzyme-linked immunosorbent assays, Southern blot and western blot).
- Cell culture (experience with primary cells and differentiation of human iPSCs are highly preferred), transduction, transfection, cell-based assays.
- Experience with manual patch clamp or automated planar patch systems will be plus.
- Perform quantitative analysis within and across multiple experiments, including basic statistical and graphical analysis.
- Work both independently and collaboratively to advance projects, perform studies with minimal supervision.
Education & Experience Requirements per level:
Research Associate 2:
- Bachelor’s degree and at least 4 years of experience; Master’s degree with at least 2 years of relevant experience
Senior Research Associate 1:
- Bachelor’s degree and at least 6 years of experience; Master’s degree with at least 4 years of relevant experience
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.