Scientist II, Mass Spectrometry Core, Center of Technology (LC MS)

Location:  San Rafael, California Category: Research


Who We Are

For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.

And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.

Our Culture

Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients’ lives.


The Center of Technology (CoTe) is a centralized laboratory built around platform technologies and made available to scientists and physicians across Worldwide Research and Development (WWRD) of BioMarin. The Mass Spectrometry (MS) Core within the CoTe provides collaboration, expert advice, service, training, and open access to state-of-the-art MS technologies to the entire scientific community of WWRD. Our lab contains 15 mass spectrometers, including Orbitraps, QQQs, Q-Traps, and Q-TOFs (ESI + MALDI).

We are searching for a highly-motivated and experienced bioanalytical scientist to develop and implement LC/MS-based bioanalytical assays and workflows that will accelerate drug discovery and development at BioMarin. This position offers a unique career opportunity to work on the entire spectrum of a product lifecycle, from early drug discovery and non-clinical work through all stages of clinical development, including post-marketing work.  The successful candidate will collaborate directly with colleagues from the CoTe, Research, and Clinical to explore a diverse range of disease areas and treatment modalities. This person will be in a position to apply LC/MS-centric platforms to accelerate drug discovery and development, while maintaining a critical eye on assay quality and maintaining regulatory standards, when applicable.



  • Develop analytical methods and workflows to quantify drugs, metabolites and biomarkers in various biological matrices. Techniques may include (but are not limited to) mass spectrometry, HPLC/UPLC, micro-flow LC and nano-flow LC.
  • Clearly and thoroughly document your work in your electronic notebook (Benchling).
  • Present results, conclusions, and implications to Research and Translation Sciences clients and early development teams.
  • Develop new workflows, or bring in new technology from the outside, to enhance the analytical capabilities of the MS Core or CoTe, more broadly.
  • Provide guidance and mentorship to junior lab staff and provide training/support to ‘self-service’ users of the MS Core.
  • Prepare SOPs and other documents such as assay development reports and data reports for testing results.
  • Share responsibility for lab management and maintenance duties.
  • Serve as Bioanalytical Study Monitor for outsourced assays, participate in audits and inspections, and adhere to regulatory compliance standards, when applicable.
  • Participate in scientific meetings and produces original peer-reviewed publications.




  • A Ph.D in Biology, Chemistry or related field with a research emphasis on mass spectrometry applications and at least 2+ years of industry experience using mass spectrometry and liquid chromatography in a biological or biochemical field. Candidates with MS and 5+ years of industry experience may also be considered.
  • Strong analytical background with proficiency in developing and optimizing quantitative LCMS assays for small molecules and proteins
  • Experience with discovery proteomics and metabolomics/lipidomics and corresponding analysis tools is desirable
  • Experience with automating sample preparation, data collection and processing would be advantageous
  • Experience with GLP and/or GCP-compliance and regulatory filing is a plus
  • Demonstrated ability to work in a fast-paced, team-oriented environment with aggressive timelines
  • Ability to interact successfully with team members from a wide variety of functional areas and diverse expertise levels.
  • Publication record supporting a consistent contribution to successfully completed projects

PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.