Scientist 1, Oligonucleotide Chemist

Location:  San Rafael, California Category: Research


Who We Are

For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.

And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.

Our Culture

Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class or best-in-class therapeutics that provide meaningful advances to patients. Come join our team and make a meaningful impact on patients’ lives.

The Oligonucleotide Group is seeking a highly motivated and talented research associate to lead oligonucleotide synthesis efforts from the bench within Research at BioMarin Pharmaceutical, Inc. We are looking for a candidate to support the design and synthesis of oligonucleotide-based therapeutics including antisense oligonucleotides and siRNA. In addition, the candidate will participate in cross-functional team efforts towards the generation of oligonucleotides for in vitro and in vivo screening, POC and MOA studies. Experience in successfully executing the synthesis, purification, and characterization of multiple oligonucleotide-based modalities is highly desired. The candidate must be ready to help drive scientific innovation with oligonucleotide-based therapeutics within the research organization at BioMarin.

The candidate will interface across different therapeutic areas including cardiology, neuroscience, musculoskeletal and hematology to help advance our most promising research programs for rare genetic diseases. The candidate will participate effectively in a multidisciplinary team and contribute to projects from in vitro through in vivo proof-of-concept studies to help drive decision making. Strong communication and collaboration skills are essential for this role. This position offers a unique career opportunity to work on exploratory research through late-stage programs with opportunities for career growth in a growing biotech company.


  • Support oligonucleotide chemistry efforts by synthesizing high-quality oligonucleotide-based modalities to meet project needs.
  • Implement new technologies to enhance drug stability, delivery, and efficacy
  • Manage oligonucleotide inventory
  • Analyze screening data and execute strategies to pursue nucleic acid chemistries for therapeutics
  • Integrate chemistry and biology data to refine oligonucleotide therapeutic development
  • Regularly review the literature for current advancements with novel nucleic acid chemistries, techniques, and delivery strategies


  • Bachelor’s degree in synthetic organic chemistry, medicinal chemistry or similar and at least 8 years of experience; Master’s degree with at least 6 years of relevant experience
  • Hands-on experience in the synthesis of oligonucleotides is required
  • Expertise in the application of oligonucleotide synthesizers (e.g. MerMade) is required
  • Knowledge of current advancements in methods oligonucleotide synthetic chemistry and characterization is desired
  • A record of accomplishments/publications in relevant scientific discipline is preferred
  • Diverse experience with nucleic acid modalities, modification chemistries, and mechanism of action is desired

PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.