RA II, Biophysical Characterization

Location:  Novato, California Category: Technical Development


Who We Are

For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more.

And the more people we reach, the more our impact can grow. We transform lives through genetic discovery.

Our Culture

Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard – so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients’ lives.


The selected candidate will work in the Biophysical Characterization team within the Analytical Sciences group to assist in the advancement of BioMarin's therapeutics for clinical evaluation and potential commercialization. The candidate will be responsible for development and qualification of new biophysical/ biochemical assays and will provide routine characterization support to partner groups to help with early candidate selection, process development, and DP/DS characterization. The ideal candidate will have hands-on experience working with AAVs and/or protein biologics with a focus on method development and analytical characterization. The candidate should be highly motivated with the ability to perform quality work under limited supervision once trained. They should possess excellent communication, collaboration, troubleshooting, and organizational skills.  


  • Be a hands-on presence in the laboratory, supporting biophysical/ biochemical assay development and qualification for various gene therapy and biologics programs.  

  • Provide routine analytical characterization support to partner groups including Upstream and Downstream PD, Formulations, and Research & Early Development (RED). 

  • Routinely document experimental results in the company electronic lab notebook (Benchling), author SOPS, and contribute to technical documentation (test methods, development reports). 

  • Actively participate in the operational aspects of the laboratory by conducting safety inspections, lab organization, ordering supplies, and performing routine equipment maintenance.  

  • Present scientific literature and results from ongoing studies at group meetings and other discussion forums at the company.  

  • Other duties as assigned. 


A B.S. or M.S. degree in Biochemistry, Biophysics, Analytical Chemistry, Chemical Engineering, Biomedical Engineering or a related field with 0-2+ years of relevant academic or industry experience. 


  • Hands-on experience in the biotechnology industry or academic setting with a broad range of techniques focused on protein or virus purification and characterization is required. 

  • Experience with some biophysical and biochemical characterization methods is required: 

  • Biochemical assays (alkaline gel electrophoresis, western blot/Wes, ELISA) 

  • Label-free binding methods (BLI/Octet, SPR) 

  • Spectroscopic methods (UV, CD, fluorescence, FRET, FRAP) 

  • Thermodynamic methods (DSC and ITC) 

  • Light scattering methods (MALS, DLS) 

  • Analytical Ultracentrifugation (AUC) 

  • Other (qPCR, ddPCR) 

  • Experience with chromatographic purification methods (HPLC, FPLC, AKTA) is preferred. 

  • Strong analytical troubleshooting skills are required. 

  • Excellent project management, verbal/written communication, and interpersonal skills are required. 

  • Knowledge of biopharmaceutical development is a plus.  

  • Experienced in method development, qualification, and transfer is a plus. 


The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

While performing the duties of this job, the employee is occasionally exposed to work near moving mechanical parts; fumes or airborne particles; toxic or caustic chemicals; risk of electrical shock and vibration. The noise level in the work environment is usually moderate.

The employee may frequently be required to sit and talk or hear. The employee is occasionally required to stand; walk; use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, kneel, crouch, or crawl and taste or smell. The employee must occasionally lift and/or move up to 25 pounds. Specific vision abilities by this job include close vision, depth perception and ability to adjust focus.


Analytical laboratory equipment.


Other scientists within Purification Process Development, Cell Culture Process Development, Analytical Chemistry, Quality Control, and Formulation; project managers, and laboratory associates.

PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.